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10.1016/j.cmet.2015.02.004 http://scihub22266oqcxt.onion/10.1016/j.cmet.2015.02.004 C4350020!4350020!25738460     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25738460&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2015 ; 21 (3): 455-67 Nephropedia Template TP {{tp|p=25738460|t=2015. A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice |pdf=|usr=}}{{25738460}} gab.com Text A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25738460 #FOAvip Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a marked reduction in plasma triglyceride levels. We show that lncLSTR depletion enhances apoC2 expression, leading to robust lipoprotein lipase activation and increased plasma triglyceride clearance. We further demonstrate that the regulation of apoC2 expression occurs through an FXR-mediated pathway. LncLSTR forms a molecular complex with TDP-43 to regulate expression of Cyp8b1, a key enzyme in the bile acid synthesis pathway, and engenders an in vivo bile pool that induces apoC2 expression through FXR. Finally, we demonstrate that lncLSTR depletion can reduce triglyceride levels in a hyperlipidemia mouse model. Taken together, these data support a model where lncLSTR regulates a TDP-43/FXR/apoC2 dependent pathway to maintain systemic lipid homeostasis. Twit Text FOAVip A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=25738460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25738460 #FOAvip English Wikipedia <ref>{{Cite pmid|25738460}}</ref> A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice #MMPMID25738460 Li P; Ruan X; Yang L; Kiesewetter K; Zhao Y; Luo H; Chen Y; Gucek M; Zhu J; Cao H Cell Metab 2015[Mar]; 21 (3): 455-67 PMID25738460show ga Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a marked reduction in plasma triglyceride levels. We show that lncLSTR depletion enhances apoC2 expression, leading to robust lipoprotein lipase activation and increased plasma triglyceride clearance. We further demonstrate that the regulation of apoC2 expression occurs through an FXR-mediated pathway. LncLSTR forms a molecular complex with TDP-43 to regulate expression of Cyp8b1, a key enzyme in the bile acid synthesis pathway, and engenders an in vivo bile pool that induces apoC2 expression through FXR. Finally, we demonstrate that lncLSTR depletion can reduce triglyceride levels in a hyperlipidemia mouse model. Taken together, these data support a model where lncLSTR regulates a TDP-43/FXR/apoC2 dependent pathway to maintain systemic lipid homeostasis. äA liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipi(epmc).pdf DeepDyve Pubget Overpricing