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10.1172/JCI79186 http://scihub22266oqcxt.onion/10.1172/JCI79186 C4348958!4348958!25401466     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2014 ; 124 (12): 5103-6 Nephropedia Template TP {{tp|p=25401466|t=2014. An animal model for progressive multifocal leukoencephalopathy |pdf=|usr=}}{{25401466}} gab.com Text An animal model for progressive multifocal leukoencephalopathy JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25401466 #FOAvip JC virus (JCV) causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease in humans. The disease, once considered fatal, is now managed with immune reconstitution therapy; however, surviving patients remain severely debilitated. Until now, there has been no animal model to study JCV in the brain, and research into treatment has relied on cell culture systems. In this issue of the JCI, Kondo and colleagues developed a mouse model in which human glial cells are engrafted into neonatal mice that are both immunodeficient and deficient for myelin basic protein. When challenged intracerebrally with JCV, these mice exhibit some of the characteristics of PML. The establishment of this chimeric mouse model is a significant advance toward understanding the mechanism of JCV pathogenesis and the identification of drugs to treat or prevent the disease. Twit Text FOAVip An animal model for progressive multifocal leukoencephalopathy ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25401466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25401466 #FOAvip English Wikipedia <ref>{{Cite pmid|25401466}}</ref> An animal model for progressive multifocal leukoencephalopathy #MMPMID25401466 Haley SA; Atwood WJ J Clin Invest 2014[Dec]; 124 (12): 5103-6 PMID25401466show ga JC virus (JCV) causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease in humans. The disease, once considered fatal, is now managed with immune reconstitution therapy; however, surviving patients remain severely debilitated. Until now, there has been no animal model to study JCV in the brain, and research into treatment has relied on cell culture systems. In this issue of the JCI, Kondo and colleagues developed a mouse model in which human glial cells are engrafted into neonatal mice that are both immunodeficient and deficient for myelin basic protein. When challenged intracerebrally with JCV, these mice exhibit some of the characteristics of PML. The establishment of this chimeric mouse model is a significant advance toward understanding the mechanism of JCV pathogenesis and the identification of drugs to treat or prevent the disease. äAn animal model for progressive multifocal leukoencephalopathy (epmc).pdf DeepDyve Pubget Overpricing