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10.1242/dmm.017699 http://scihub22266oqcxt.onion/10.1242/dmm.017699 C4348565!4348565 !25633980     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25633980 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis |pdf=|usr=}}{{25633980 }} gab.com Text Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis JO: Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=25633980 #FOAvip Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis to evaluate the efficacy of cell-based therapy in preclinical (animal) studies of CKD, and determined factors affecting cell-based therapy efficacy in order to guide future clinical trials. In total, 71 articles met the inclusion criteria. Standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated for outcome parameters including plasma urea, plasma creatinine, urinary protein, blood pressure, glomerular filtration rate, glomerulosclerosis and interstitial fibrosis. Sub-analysis for each outcome measure was performed for model-related factors (species, gender, model and timing of therapy) and cell-related factors (cell type, condition and origin, administration route and regime of therapy). Overall, meta-analysis showed that cell-based therapy reduced the development and progression of CKD. This was most prominent for urinary protein (SMD, 1.34; 95% CI, 1.00-1.68) and urea (1.09; 0.66-1.51), both P<0.001. Changes in plasma urea were associated with changes in both glomerulosclerosis and interstitial fibrosis. Sub-analysis showed that cell type (bone-marrow-derived progenitors and mesenchymal stromal cells being most effective) and administration route (intravenous or renal artery injection) were significant predictors of therapeutic efficacy. The timing of therapy in relation to clinical manifestation of disease, and cell origin and dose, were not associated with efficacy. Our meta-analysis confirms that cell-based therapies improve impaired renal function and morphology in preclinical models of CKD. Our analyses can be used to optimise experimental interventions and thus support both improved preclinical research and development of cell-based therapeutic interventions in a clinical setting. Twit Text FOAVip Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis ????Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=25633980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25633980 #FOAvip English Wikipedia <ref>{{Cite pmid|25633980 }}</ref> Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis #MMPMID25633980 Papazova DA ; Oosterhuis NR ; Gremmels H ; van Koppen A ; Joles JA ; Verhaar MC Dis Model Mech 2015[Mar]; 8 (3 ): 281-93 PMID25633980 show ga Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis to evaluate the efficacy of cell-based therapy in preclinical (animal) studies of CKD, and determined factors affecting cell-based therapy efficacy in order to guide future clinical trials. In total, 71 articles met the inclusion criteria. Standardised mean differences (SMD) and 95% confidence intervals (CI) were calculated for outcome parameters including plasma urea, plasma creatinine, urinary protein, blood pressure, glomerular filtration rate, glomerulosclerosis and interstitial fibrosis. Sub-analysis for each outcome measure was performed for model-related factors (species, gender, model and timing of therapy) and cell-related factors (cell type, condition and origin, administration route and regime of therapy). Overall, meta-analysis showed that cell-based therapy reduced the development and progression of CKD. This was most prominent for urinary protein (SMD, 1.34; 95% CI, 1.00-1.68) and urea (1.09; 0.66-1.51), both P<0.001. Changes in plasma urea were associated with changes in both glomerulosclerosis and interstitial fibrosis. Sub-analysis showed that cell type (bone-marrow-derived progenitors and mesenchymal stromal cells being most effective) and administration route (intravenous or renal artery injection) were significant predictors of therapeutic efficacy. The timing of therapy in relation to clinical manifestation of disease, and cell origin and dose, were not associated with efficacy. Our meta-analysis confirms that cell-based therapies improve impaired renal function and morphology in preclinical models of CKD. Our analyses can be used to optimise experimental interventions and thus support both improved preclinical research and development of cell-based therapeutic interventions in a clinical setting. |*Cell- and Tissue-Based Therapy [MESH] |Animals [MESH] |Blood Pressure [MESH] |Disease Models, Animal [MESH] |Kidney/pathology/physiopathology [MESH] |Outcome Assessment, Health Care [MESH] |Proteinuria/blood/complications/metabolism [MESH] |Publication Bias [MESH] |Regression Analysis [MESH] |Renal Insufficiency, Chronic/blood/complications/physiopathology/*therapy [MESH]Cell-based therapies for experimental chronic kidney disease: a system(epmc).pdf DeepDyve Pubget Overpricing