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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cereb+Blood+Flow+Metab
2015 ; 35
(3
): 494-500
Nephropedia Template TP
gab.com Text
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English Wikipedia
Hydrogen sulfide inhalation decreases early blood-brain barrier permeability and
brain edema induced by cardiac arrest and resuscitation
#MMPMID25492119
Geng Y
; Li E
; Mu Q
; Zhang Y
; Wei X
; Li H
; Cheng L
; Zhang B
J Cereb Blood Flow Metab
2015[Mar]; 35
(3
): 494-500
PMID25492119
show ga
The effects of hydrogen sulfide (H2S) on blood-brain barrier (BBB) and brain
edema after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) remain
poorly understood. We investigated the effects of exogenous 80-p.p.m. H2S gas on
BBB, brain water content, neurologic outcome, and survival rate after CA and CPR.
Cardiopulmonary resuscitation followed CA induced in rats by ventricular
fibrillation for 6?minutes. Results show that inhalation of 80-p.p.m. H2S
significantly reduced the permeability of the BBB in both in the cortex and
hippocampus at 24?hours after resuscitation. Hydrogen sulfide also lessened brain
edema in the cortex and hippocampus, ameliorated neurologic outcome as evaluated
by neurologic deficit score and tape removal test, and improved the 14-day
survival rate. Hydrogen sulfide also attenuated CA and CPR-induced increases of
matrix metalloproteinase-9 (MMP-9) activity and vascular endothelial growth
factor (VEGF) expression, and increased the expression of angiogenin-1 (Ang-1).
These results indicate that inhalation of 80-p.p.m. H2S immediately after CPR
attenuated BBB permeability and brain edema, and improved neurologic outcome and
14-day survival of rats after CA. The therapeutic benefits of H2S could be
associated with suppression of MMP-9 and VEGF expression and increased expression
of Ang-1.