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2015 ; 52
(3
): 1434-43
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Protective effect of Monascus fermented rice against STZ-induced diabetic
oxidative stress in kidney of rats
#MMPMID25745211
Rajasekaran A
; Kalaivani M
J Food Sci Technol
2015[Mar]; 52
(3
): 1434-43
PMID25745211
show ga
In the present study, anti-diabetic activity and nephroprotective effect of MMFR
was evaluated by using STZ-induced diabetic rats. Administration of MMFR at 100
and 200 mg/kg bw showed significant (P?0.01) anti-hyperglycemic activity by
lowering blood glucose level, HbA1C and increasing body weight. Altered lipid
profiles in diabetic rats were restored to normal level on treatment with MMFR
and showed significant (P?0.01) decrease in the elevated levels of biochemical
parameters. MMFR produced significant (P?0.01) improvement in antioxidant
levels in kidney. Food safety of MFR produced by using mutant Monascus purpureus
254 (MMFR) was evaluated for genotoxicity and oral acute toxicity. In Ames
mutagenicity assay MMFR doesn't showed any toxicity to the test strain S.
typhimurium till 5 mg/plate. Acute toxicity study also recorded no toxicity till
the dose of 5,000 mg/kg bw. The study concluded that MMFR, not only possess
anti-diabetic activity but also prevents nephropathy and hypercholesterolemia due
to diabetes.