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10.1158/0008-5472.CAN-14-2568

http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2568
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C4348149!4348149!25660948
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suck abstract from ncbi


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pmid25660948      Cancer+Res 2015 ; 75 (5): 783-91
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  • Signaling-mediated Regulation of MicroRNA Processing #MMPMID25660948
  • Shen J; Hung MC
  • Cancer Res 2015[Mar]; 75 (5): 783-91 PMID25660948show ga
  • MicroRNAs (miRNAs) are important regulatory elements for gene expression that are involved in diverse physiological and pathological processes. Canonical miRNA biogenesis consists of a two-step processing, from primary transcripts (pri-miRNAs) to precursor miRNAs (pre-miRNAs) mediated by Drosha in the nucleus and from pre-miRNAs to mature miRNAs mediated by Dicer in the cytoplasm. Various routes of miRNA maturation that are tightly regulated by signaling cascades and specific to an individual or a subclass of miRNAs have been recently identified. Here, we review the current findings in signaling-mediated miRNA processing as well as their potential clinical relevance in cancer.
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