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10.3390/ijms16024226 http://scihub22266oqcxt.onion/10.3390/ijms16024226 C4346954!4346954!25690036     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (2): 4226-49 Nephropedia Template TP {{tp|p=25690036|t=2015. Potential Role of Dipeptidyl Peptidase IV in the Pathophysiology of Heart Failure |pdf=|usr=}}{{25690036}} gab.com Text Potential Role of Dipeptidyl Peptidase IV in the Pathophysiology of Heart Failure JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25690036 #FOAvip Dipeptidyl peptidase IV (DPPIV) is a widely expressed multifunctional serine peptidase that exists as a membrane-anchored cell surface protein or in a soluble form in the plasma and other body fluids. Numerous substrates are cleaved at the penultimate amino acid by DPPIV, including glucagon-like peptide-1 (GLP-1), brain natriuretic peptide (BNP) and stromal cell-derived factor-1 (SDF-?), all of which play important roles in the cardiovascular system. In this regard, recent reports have documented that circulating DPPIV activity correlates with poorer cardiovascular outcomes in human and experimental heart failure (HF). Moreover, emerging evidence indicates that DPPIV inhibitors exert cardioprotective and renoprotective actions in a variety of experimental models of cardiac dysfunction. On the other hand, conflicting results have been found when translating these promising findings from preclinical animal models to clinical therapy. In this review, we discuss how DPPIV might be involved in the cardio-renal axis in HF. In addition, the potential role for DPPIV inhibitors in ameliorating heart disease is revised, focusing on the effects of the main DPPIV substrates on cardiac remodeling and renal handling of salt and water. Twit Text FOAVip Potential Role of Dipeptidyl Peptidase IV in the Pathophysiology of Heart Failure ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25690036 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25690036 #FOAvip English Wikipedia <ref>{{Cite pmid|25690036}}</ref> Potential Role of Dipeptidyl Peptidase IV in the Pathophysiology of Heart Failure #MMPMID25690036 Salles TA; dos Santos L; Barauna VG; Girardi ACC Int J Mol Sci 2015[Feb]; 16 (2): 4226-49 PMID25690036show ga Dipeptidyl peptidase IV (DPPIV) is a widely expressed multifunctional serine peptidase that exists as a membrane-anchored cell surface protein or in a soluble form in the plasma and other body fluids. Numerous substrates are cleaved at the penultimate amino acid by DPPIV, including glucagon-like peptide-1 (GLP-1), brain natriuretic peptide (BNP) and stromal cell-derived factor-1 (SDF-?), all of which play important roles in the cardiovascular system. In this regard, recent reports have documented that circulating DPPIV activity correlates with poorer cardiovascular outcomes in human and experimental heart failure (HF). Moreover, emerging evidence indicates that DPPIV inhibitors exert cardioprotective and renoprotective actions in a variety of experimental models of cardiac dysfunction. On the other hand, conflicting results have been found when translating these promising findings from preclinical animal models to clinical therapy. In this review, we discuss how DPPIV might be involved in the cardio-renal axis in HF. In addition, the potential role for DPPIV inhibitors in ameliorating heart disease is revised, focusing on the effects of the main DPPIV substrates on cardiac remodeling and renal handling of salt and water. äPotential Role of Dipeptidyl Peptidase IV in the Pathophysiology of He(epmc).pdf DeepDyve Pubget Overpricing