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2015 ; 16
(2
): 3307-22
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Significant roles of regulatory T cells and myeloid derived suppressor cells in
hepatitis B virus persistent infection and hepatitis B virus-related HCCs
#MMPMID25654227
Kondo Y
; Shimosegawa T
Int J Mol Sci
2015[Feb]; 16
(2
): 3307-22
PMID25654227
show ga
The adaptive immune system, including type1 helper T cells (Th1 cells), cytotoxic
T lymphocytes (CTLs), and dendritic cells (DCs), plays an important role in the
control of hepatitis B virus (HBV). On the other hand, regulatory T cells (Tregs)
and myeloid derived suppressor cells (MDSCs) suppress the immune reaction in HBV
and hepatocellular carcinoma (HCC). Excessive activation of immune suppressive
cells could contribute to the persistent infection of HBV and the progression of
HCC. The frequency and/or function of Tregs could affect the natural course in
chronic hepatitis B patients and the treatment response. In addition to the
suppressive function of MDSCs, MDSCs could affect the induction and function of
Tregs. Therefore, we should understand in detail the mechanism by which Tregs and
MDSCs are induced to control HBV persistent infection and HBV-related HCC. Immune
suppressive cells, including Tregs and MDSCs, contribute to the difficulty in
inducing an effective immune response for HBV persistent infection and
HBV-related HCC. In this review, we focus on the Tregs and MDSCs that could be
potential targets for immune therapy of chronic hepatitis B and HBV-related HCC.