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2014 ; 1
(3
): 27-32
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English Wikipedia
Probability of Regenerating a Normal Limb After Bite Injury in the Mexican
Axolotl (Ambystoma mexicanum)
#MMPMID25745564
Thompson S
; Muzinic L
; Muzinic C
; Niemiller ML
; Voss SR
Regeneration (Oxf)
2014[Jun]; 1
(3
): 27-32
PMID25745564
show ga
Multiple factors are thought to cause limb abnormalities in amphibian populations
by altering processes of limb development and regeneration. We examined adult and
juvenile axolotls (Ambystoma mexicanum) in the Ambystoma Genetic Stock Center
(AGSC) for limb and digit abnormalities to investigate the probability of normal
regeneration after bite injury. We observed that 80% of larval salamanders show
evidence of bite injury at the time of transition from group housing to solitary
housing. Among 717 adult axolotls that were surveyed, which included
solitary-housed males and group-housed females, approximately half presented
abnormalities, including examples of extra or missing digits and limbs, fused
digits, and digits growing from atypical anatomical positions. Bite injury likely
explains these limb defects, and not abnormal development, because limbs with
normal anatomy regenerated after performing rostral amputations. We infer that
only 43% of AGSC larvae will present four anatomically normal looking adult limbs
after incurring a bite injury. Our results show regeneration of normal limb
anatomy to be less than perfect after bite injury.