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10.1002/ejp.583 http://scihub22266oqcxt.onion/10.1002/ejp.583 C4345163!4345163!25168788     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pain 2015 ; 19 (5): 621-8 Nephropedia Template TP {{tp|p=25168788|t=2015. Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post-traumatic headache |pdf=|usr=}}{{25168788}} gab.com Text Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post-traumatic headache JO: Eur J Pain http://www.kidney.de/pget.php?&tw=1&pmid=25168788 #FOAvip Background: Headache is one of the most common symptoms following traumatic head injury. The mechanisms underlying the emergence of such post-traumatic headache (PTH) remain unknown but may be related to injury of deep cranial tissues or damage to central pain processing pathways, as a result of brain injury. Methods: A mild closed head injury in mice combined with the administration of cranial or hindpaw formalin tests were used to examine post-traumatic changes in the nociceptive processing from deep cranial tissues or the hindpaw. Histological analysis was used to examine post-traumatic pro-inflammatory changes in the calvarial periosteum, a deep cranial tissue. Results: At 48 hours after head injury, mice demonstrated enhanced nociceptive responses following injection of formalin into the calvarial periosteum, a deep cranial tissue, but no facilitation of the nociceptive responses following injection of formalin into an extracranial tissue, the hindpaw. Mice also showed an increase in the number of activated periosteal mast cells 48 hours following mild head trauma, suggesting an inflammatory response. Conclusion: Our study demonstrates that mild closed head injury is associated with enhanced processing of nociceptive information emanating from trigeminal-innervated deep cranial tissues, but not from non-cranial tissues. Based on these finding as well as the demonstration of head injury-evoked degranulation of calvarial periosteal mast cells, we propose that inflammatory-evoked enhancement of peripheral cranial nociception, rather than changes in supraspinal pain mechanisms play a role in the initial emergence of PTH. Peripheral targeting of nociceptors that innervate the calvaria may be used to ameliorate PTH pain. Twit Text FOAVip Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post-traumatic headache ????Eur J Pain http://www.kidney.de/pget.php?&tw=1&pmid=25168788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25168788 #FOAvip English Wikipedia <ref>{{Cite pmid|25168788}}</ref> Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post-traumatic headache #MMPMID25168788 Benromano T; Defrin R; Ahn AH; Zhao J; Pick CG; Levy D Eur J Pain 2015[May]; 19 (5): 621-8 PMID25168788show ga Background: Headache is one of the most common symptoms following traumatic head injury. The mechanisms underlying the emergence of such post-traumatic headache (PTH) remain unknown but may be related to injury of deep cranial tissues or damage to central pain processing pathways, as a result of brain injury. Methods: A mild closed head injury in mice combined with the administration of cranial or hindpaw formalin tests were used to examine post-traumatic changes in the nociceptive processing from deep cranial tissues or the hindpaw. Histological analysis was used to examine post-traumatic pro-inflammatory changes in the calvarial periosteum, a deep cranial tissue. Results: At 48 hours after head injury, mice demonstrated enhanced nociceptive responses following injection of formalin into the calvarial periosteum, a deep cranial tissue, but no facilitation of the nociceptive responses following injection of formalin into an extracranial tissue, the hindpaw. Mice also showed an increase in the number of activated periosteal mast cells 48 hours following mild head trauma, suggesting an inflammatory response. Conclusion: Our study demonstrates that mild closed head injury is associated with enhanced processing of nociceptive information emanating from trigeminal-innervated deep cranial tissues, but not from non-cranial tissues. Based on these finding as well as the demonstration of head injury-evoked degranulation of calvarial periosteal mast cells, we propose that inflammatory-evoked enhancement of peripheral cranial nociception, rather than changes in supraspinal pain mechanisms play a role in the initial emergence of PTH. Peripheral targeting of nociceptors that innervate the calvaria may be used to ameliorate PTH pain. äMild closed head injury promotes a selective trigeminal hypernocicepti(epmc).pdf DeepDyve Pubget Overpricing