Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncb3109 http://scihub22266oqcxt.onion/10.1038/ncb3109 C4344897!4344897!25686250     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2015 ; 17 (3): 228-40 Nephropedia Template TP {{tp|p=25686250|t=2015. Early steps in primary cilium assembly require EHD1- and EHD3-dependent ciliary vesicle formation |pdf=|usr=}}{{25686250}} gab.com Text Early steps in primary cilium assembly require EHD1- and EHD3-dependent ciliary vesicle formation JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25686250 #FOAvip Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to pre-ciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle (CV) formation from smaller distal appendage vesicles (DAV). Importantly, this step functions in M-centriole to basal body transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated CV assembly. Interestingly, only after CV assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step whereby EHD1 and EHD3 reorganize the M-centriole and associated DAV prior to coordinated ciliary membrane and axoneme growth. Twit Text FOAVip Early steps in primary cilium assembly require EHD1- and EHD3-dependent ciliary vesicle formation ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25686250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25686250 #FOAvip English Wikipedia <ref>{{Cite pmid|25686250}}</ref> Early steps in primary cilium assembly require EHD1- and EHD3-dependent ciliary vesicle formation #MMPMID25686250 Lu Q; Insinna C; Ott C; Stauffer J; Pintado PA; Rahajeng J; Baxa U; Walia V; Cuenca A; Hwang YS; Daar IO; Lopes S; Lippincott-Schwartz J; Jackson PK; Caplan S; Westlake CJ Nat Cell Biol 2015[Mar]; 17 (3): 228-40 PMID25686250show ga Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to pre-ciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle (CV) formation from smaller distal appendage vesicles (DAV). Importantly, this step functions in M-centriole to basal body transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated CV assembly. Interestingly, only after CV assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step whereby EHD1 and EHD3 reorganize the M-centriole and associated DAV prior to coordinated ciliary membrane and axoneme growth. äEarly steps in primary cilium assembly require EHD1- and EHD3-dependen(epmc).pdf DeepDyve Pubget Overpricing