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10.1002/dvdy.24234

http://scihub22266oqcxt.onion/10.1002/dvdy.24234
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C4344844!4344844!25470458
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suck abstract from ncbi


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pmid25470458      Dev+Dyn 2015 ; 244 (3): 342-66
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  • Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development #MMPMID25470458
  • Volckaert T; De Langhe SP
  • Dev Dyn 2015[Mar]; 244 (3): 342-66 PMID25470458show ga
  • The adaptation to terrestrial life required the development of an organ capable of efficient air-blood gas exchange. To meet the metabolic load of cellular respiration, the mammalian respiratory system has evolved from a relatively simple structure, similar to the two-tube amphibian lung, to a highly complex tree-like system of branched epithelial airways connected to a vast network of gas exchanging units called alveoli. The development of such an elaborate organ in a relatively short time window is therefore an extraordinary feat and involves an intimate crosstalk between mesodermal and endodermal cell lineages. This review describes the molecular processes governing lung development with an emphasis on the current knowledge on the role of Wnt and Fgf signaling in lung epithelial differentiation.
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