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10.1007/s00018-014-1790-1

http://scihub22266oqcxt.onion/10.1007/s00018-014-1790-1
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C4342274!4342274!25428780
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suck abstract from ncbi


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pmid25428780      Cell+Mol+Life+Sci 2015 ; 72 (6): 1161-73
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  • Protective role of Hemeoxygenase-1 in Gastrointestinal Diseases #MMPMID25428780
  • Chang M; Xue J; Sharma V; Habtezion A
  • Cell Mol Life Sci 2015[Mar]; 72 (6): 1161-73 PMID25428780show ga
  • Disorders and diseases of the gastrointestinal system encompass a wide array of pathogenic mechanisms as a result of genetic, infectious, neoplastic, and inflammatory conditions. Inflammatory diseases in general are rising in incidence and are emerging clinical problems in gastroenterology and hepatology. Hemeoxygenase-1 (HO-1) is a stress-inducible enzyme that has been shown to confer protection in various organ-system models. Its downstream effectors, carbon monoxide and biliverdin have also been shown to offer these beneficial effects. Many studies suggest that induction of HO-1 expression in gastrointestinal tissues and cells plays a critical role in cytoprotection and resolving inflammation as well as tissue injury. In this review we examine the protective role of HO-1 and its downstream effectors in modulating inflammatory diseases of the upper (esophagus and stomach) and lower (small and large intestine) gastrointestinal tract, the liver, and the pancreas. Cytoprotective, anti-inflammatory, anti-proliferative, anti-oxidant, and anti-apoptotic activities of HO-1 make it a promising if not ideal therapeutic target for inflammatory diseases of the gastrointestinal system.
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