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10.1681/ASN.2014030297 http://scihub22266oqcxt.onion/10.1681/ASN.2014030297 C4341484!4341484!25074509     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2015 ; 26 (3): 746-53 Nephropedia Template TP {{tp|p=25074509|t=2015. Imaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Disease |pdf=|usr=}}{{25074509}} gab.com Text Imaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Disease JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25074509 #FOAvip The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic kidney disease (ADPKD) is currently limited by reduced diagnostic sensitivity, especially in at-risk subjects younger than 30 years of age. In this single-center prospective study, we compared the diagnostic performance of MRI with that of high-resolution (HR) US in 126 subjects ages 16?40 years born with a 50% risk of ADPKD who underwent both these renal imaging studies and comprehensive PKD1 and PKD2 mutation screening. Concurrently, 45 healthy control subjects without a family history of ADPKD completed the same imaging protocol. We analyzed 110 at-risk subjects whose disease status was unequivocally defined by molecular testing and 45 unaffected healthy control subjects. Using a total of >10 cysts as a test criterion in subjects younger than 30 years of age, we found that MRI provided both a sensitivity and specificity of 100%. Comparison of our results from HR US with those from a previous study of conventional US using the test criterion of a total of three or more cysts found a higher diagnostic sensitivity (approximately 97% versus approximately 82%) with a slightly decreased specificity (approximately 98% versus 100%) in this study. Similar results were obtained in test subjects between the ages of 30 and 40 years old. These results suggest that MRI is highly sensitive and specific for diagnosis of ADPKD. HR US has the potential to rival the diagnostic performance of MRI but is both center- and operator-dependent. Twit Text FOAVip Imaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Disease ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25074509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25074509 #FOAvip English Wikipedia <ref>{{Cite pmid|25074509}}</ref> Imaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Disease #MMPMID25074509 Pei Y; Hwang YH; Conklin J; Sundsbak JL; Heyer CM; Chan W; Wang K; He N; Rattansingh A; Atri M; Harris PC; Haider MA J Am Soc Nephrol 2015[Mar]; 26 (3): 746-53 PMID25074509show ga The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic kidney disease (ADPKD) is currently limited by reduced diagnostic sensitivity, especially in at-risk subjects younger than 30 years of age. In this single-center prospective study, we compared the diagnostic performance of MRI with that of high-resolution (HR) US in 126 subjects ages 16?40 years born with a 50% risk of ADPKD who underwent both these renal imaging studies and comprehensive PKD1 and PKD2 mutation screening. Concurrently, 45 healthy control subjects without a family history of ADPKD completed the same imaging protocol. We analyzed 110 at-risk subjects whose disease status was unequivocally defined by molecular testing and 45 unaffected healthy control subjects. Using a total of >10 cysts as a test criterion in subjects younger than 30 years of age, we found that MRI provided both a sensitivity and specificity of 100%. Comparison of our results from HR US with those from a previous study of conventional US using the test criterion of a total of three or more cysts found a higher diagnostic sensitivity (approximately 97% versus approximately 82%) with a slightly decreased specificity (approximately 98% versus 100%) in this study. Similar results were obtained in test subjects between the ages of 30 and 40 years old. These results suggest that MRI is highly sensitive and specific for diagnosis of ADPKD. HR US has the potential to rival the diagnostic performance of MRI but is both center- and operator-dependent. äImaging-Based Diagnosis of Autosomal Dominant Polycystic Kidney Diseas(epmc).pdf DeepDyve Pubget Overpricing