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10.1681/ASN.2013090980 http://scihub22266oqcxt.onion/10.1681/ASN.2013090980 C4341468!4341468 !25071086     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25071086 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy |pdf=|usr=}}{{25071086 }} gab.com Text Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25071086 #FOAvip In the kidney, 20-hydroxyeicosatetraenoic acid (20-HETE) is a primary cytochrome P450 4 (Cyp4)-derived eicosanoid that enhances vasoconstriction of renal vessels and induces hypertension, renal tubular cell hypertrophy, and podocyte apoptosis. Hypertension and podocyte injury contribute to diabetic nephropathy and are strong predictors of disease progression. In this study, we defined the mechanisms whereby 20-HETE affects the progression of diabetic nephropathy. We used Cyp4a14KO male mice that exhibit androgen-sensitive hypertension due to increased Cyp4a12-mediated 20-HETE production. We show that, upon induction of diabetes type 1 via streptozotocin injection, Cyp4a14KO male mice developed worse renal disease than streptozotocin-treated wild-type mice, characterized by increased albuminuria, mesangial expansion, glomerular matrix deposition, and thickness of the glomerular basement membranes. Castration blunted androgen-mediated Cyp4a12 synthesis and 20-HETE production, normalized BP, and ameliorated renal damage in diabetic Cyp4a14KO mice. Notably, treatment with a 20-HETE antagonist or agents that normalized BP without affecting Cyp4a12 expression and 20-HETE biosynthesis also ameliorated diabetes-mediated renal damage and albuminuria in Cyp4a14KO male mice. Taken together, these results suggest that hypertension is the major contributor to 20-HETE-driven diabetes-mediated kidney injury. Twit Text FOAVip Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25071086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25071086 #FOAvip English Wikipedia <ref>{{Cite pmid|25071086 }}</ref> Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy #MMPMID25071086 Gangadhariah MH ; Luther JM ; Garcia V ; Paueksakon P ; Zhang MZ ; Hayward SW ; Love HD ; Falck JR ; Manthati VL ; Imig JD ; Schwartzman ML ; Zent R ; Capdevila JH ; Pozzi A J Am Soc Nephrol 2015[Mar]; 26 (3 ): 597-610 PMID25071086 show ga In the kidney, 20-hydroxyeicosatetraenoic acid (20-HETE) is a primary cytochrome P450 4 (Cyp4)-derived eicosanoid that enhances vasoconstriction of renal vessels and induces hypertension, renal tubular cell hypertrophy, and podocyte apoptosis. Hypertension and podocyte injury contribute to diabetic nephropathy and are strong predictors of disease progression. In this study, we defined the mechanisms whereby 20-HETE affects the progression of diabetic nephropathy. We used Cyp4a14KO male mice that exhibit androgen-sensitive hypertension due to increased Cyp4a12-mediated 20-HETE production. We show that, upon induction of diabetes type 1 via streptozotocin injection, Cyp4a14KO male mice developed worse renal disease than streptozotocin-treated wild-type mice, characterized by increased albuminuria, mesangial expansion, glomerular matrix deposition, and thickness of the glomerular basement membranes. Castration blunted androgen-mediated Cyp4a12 synthesis and 20-HETE production, normalized BP, and ameliorated renal damage in diabetic Cyp4a14KO mice. Notably, treatment with a 20-HETE antagonist or agents that normalized BP without affecting Cyp4a12 expression and 20-HETE biosynthesis also ameliorated diabetes-mediated renal damage and albuminuria in Cyp4a14KO male mice. Taken together, these results suggest that hypertension is the major contributor to 20-HETE-driven diabetes-mediated kidney injury. |Animals [MESH] |Collagen/metabolism [MESH] |Cytochrome P-450 Enzyme System/genetics/*metabolism [MESH] |Cytochrome P450 Family 4 [MESH] |Diabetic Nephropathies/*etiology/pathology [MESH] |Glomerular Basement Membrane/pathology [MESH] |Hydralazine [MESH] |Hydrochlorothiazide [MESH] |Hydroxyeicosatetraenoic Acids/antagonists & inhibitors/*metabolism [MESH] |Hypertension/*complications [MESH] |Male [MESH] |Mice, Knockout [MESH] |Orchiectomy [MESH] |Renin-Angiotensin System [MESH] |Reserpine [MESH]Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid(epmc).pdf DeepDyve Pubget Overpricing