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10.1038/nn.3930 http://scihub22266oqcxt.onion/10.1038/nn.3930 C4340760!4340760!25622143     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2015 ; 18 (3): 423-34 Nephropedia Template TP {{tp|p=25622143|t=2015. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory |pdf=|usr=}}{{25622143}} gab.com Text Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25622143 #FOAvip Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not known. We found that humans with Alzheimer?s disease (AD) had increased levels of the Gs-coupled adenosine receptor A2A in astrocytes. Conditional genetic removal of these receptors enhanced long-term memory in young and aging mice, and increased the levels of Arc/Arg3.1, an immediate-early gene required for long-term memory. Chemogenetic activation of astrocytic Gs-coupled signaling reduced long-term memory in mice without affecting learning. Similar to humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels of astrocytic A2A receptors. Conditional genetic removal of these receptors enhanced memory in aging hAPP mice. Together, these findings establish a regulatory role for astrocytic Gs-coupled receptors in memory and suggest that AD-linked increases in astrocytic A2A receptor levels contribute to memory loss. Twit Text FOAVip Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25622143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25622143 #FOAvip English Wikipedia <ref>{{Cite pmid|25622143}}</ref> Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory #MMPMID25622143 Orr AG; Hsiao EC; Wang MM; Ho K; Kim DH; Wang X; Guo W; Kang J; Yu GQ; Adame A; Devidze N; Dubal DB; Masliah E; Conklin BR; Mucke L Nat Neurosci 2015[Mar]; 18 (3): 423-34 PMID25622143show ga Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not known. We found that humans with Alzheimer?s disease (AD) had increased levels of the Gs-coupled adenosine receptor A2A in astrocytes. Conditional genetic removal of these receptors enhanced long-term memory in young and aging mice, and increased the levels of Arc/Arg3.1, an immediate-early gene required for long-term memory. Chemogenetic activation of astrocytic Gs-coupled signaling reduced long-term memory in mice without affecting learning. Similar to humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels of astrocytic A2A receptors. Conditional genetic removal of these receptors enhanced memory in aging hAPP mice. Together, these findings establish a regulatory role for astrocytic Gs-coupled receptors in memory and suggest that AD-linked increases in astrocytic A2A receptor levels contribute to memory loss. äAstrocytic adenosine receptor A2A and Gs-coupled signaling regulate me(epmc).pdf DeepDyve Pubget Overpricing