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10.4049/jimmunol.1402951 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402951 C4340749!4340749!25637014     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (5): 2064-7 Nephropedia Template TP {{tp|p=25637014|t=2015. SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation |pdf=|usr=}}{{25637014}} gab.com Text SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25637014 #FOAvip The NLRP3 inflammasome is a multimeric protein complex assembled in response to a wide array of pathogens and danger-associated molecular patterns. Despite the ability of NLRP3 to respond to diverse cues, the mechanisms controlling assembly of this complex are contested. Recently published studies show that HOIL-1, a member of the linear ubiquitin chain assembly complex (LUBAC), contributes to activation of the NLRP3 inflammasome. SHARPIN, along with HOIP and HOIL-1 assembles the LUBAC complex. Herein, we examined whether SHARPIN is required for the activation of NLRP3 inflammasome. Utilizing Sharpincpdm macrophages (deficient in SHARPIN expression), we demonstrate that SHARPIN is required for optimal activation of the NLRP3 inflammasome by both canonical and non-canonical stimuli. Furthermore, Sharpincpdm macrophages had dramatic defects in both NF?B and MAP kinase pathways, suggesting a role in transcriptional priming of the NLRP3 inflammasome. In conclusion, our study identified SHARPIN as a novel regulator of the NLRP3 inflammasome. Twit Text FOAVip SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25637014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25637014 #FOAvip English Wikipedia <ref>{{Cite pmid|25637014}}</ref> SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation #MMPMID25637014 Gurung P; Lamkanfi M; Kanneganti TD J Immunol 2015[Mar]; 194 (5): 2064-7 PMID25637014show ga The NLRP3 inflammasome is a multimeric protein complex assembled in response to a wide array of pathogens and danger-associated molecular patterns. Despite the ability of NLRP3 to respond to diverse cues, the mechanisms controlling assembly of this complex are contested. Recently published studies show that HOIL-1, a member of the linear ubiquitin chain assembly complex (LUBAC), contributes to activation of the NLRP3 inflammasome. SHARPIN, along with HOIP and HOIL-1 assembles the LUBAC complex. Herein, we examined whether SHARPIN is required for the activation of NLRP3 inflammasome. Utilizing Sharpincpdm macrophages (deficient in SHARPIN expression), we demonstrate that SHARPIN is required for optimal activation of the NLRP3 inflammasome by both canonical and non-canonical stimuli. Furthermore, Sharpincpdm macrophages had dramatic defects in both NF?B and MAP kinase pathways, suggesting a role in transcriptional priming of the NLRP3 inflammasome. In conclusion, our study identified SHARPIN as a novel regulator of the NLRP3 inflammasome. äSHANK-associated RH domain interacting protein (SHARPIN) is required f(epmc).pdf DeepDyve Pubget Overpricing