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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pflugers+Arch 2015 ; 467 (3): 551-8 Nephropedia Template TP
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Tissue sodium storage: evidence for kidney-like extrarenal countercurrent systems? #MMPMID25600900
Hofmeister LH; Perisic S; Titze J
Pflugers Arch 2015[Mar]; 467 (3): 551-8 PMID25600900show ga
Recent evidence from chemical analysis of tissue electrolyte and water composition has shown that body Na+ content in experimental animals is not constant, does not always readily equilibrate with water, and cannot be exclusively controlled by the renal blood purification process. Instead, large amounts of Na+ are stored in the skin and in skeletal muscle. Quantitative non-invasive detection of Na+ reservoirs with 23NaMRI suggests that this mysterious Na+ storage is not only an animal research curiosity, but also exists in humans. In clinical studies, tissue Na+ storage is closely associated with essential hypertension. In animal experiments, modulation of reservoir tissue Na+ content leads to predictable blood pressure changes. The available evidence thus suggests that the patho(?)-physiological process of Na+ storage might be even of relevance for human health and disease.