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10.1038/nchembio.1712

http://scihub22266oqcxt.onion/10.1038/nchembio.1712
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C4340667!4340667!25517383
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suck abstract from ncbi

pmid25517383      Nat+Chem+Biol 2015 ; 11 (1): 9-15
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  • Targeting mitochondria metabolism for cancer therapy #MMPMID25517383
  • Weinberg SE; Chandel NS
  • Nat Chem Biol 2015[Jan]; 11 (1): 9-15 PMID25517383show ga
  • Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.
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