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10.1038/nn.3943 http://scihub22266oqcxt.onion/10.1038/nn.3943 C4340083!4340083!25710834     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2015 ; 18 (3): 331-8 Nephropedia Template TP {{tp|p=25710834|t=2015. Beyond the hammer and the scalpel: selective circuit control for the epilepsies |pdf=|usr=}}{{25710834}} gab.com Text Beyond the hammer and the scalpel: selective circuit control for the epilepsies JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25710834 #FOAvip Current treatment options for epilepsy are inadequate as too many patients suffer from uncontrolled seizures and from negative side effects of treatment. Along with major challenges in treatment, scientific understanding of epilepsy is also incomplete, with key questions in epilepsy research remaining unanswered. The major benefit of optogenetic and designer receptor technology is the unprecedented and much needed specificity they provide, allowing spatial, temporal, and cell-type selective modulation of neuronal circuits. Equipped with such tools, it is now possible to begin to address some of the fundamental unanswered questions in epilepsy, to dissect epileptic neuronal circuits, and to develop new intervention strategies. Such specificity of intervention also has the potential for direct therapeutic benefits, allowing healthy tissue and network functions to continue unaffected. In this Perspective, we discuss promising uses of these technologies for the study of seizures and epilepsy, as well as potential use of these strategies for clinical therapies. Twit Text FOAVip Beyond the hammer and the scalpel: selective circuit control for the epilepsies ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25710834 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25710834 #FOAvip English Wikipedia <ref>{{Cite pmid|25710834}}</ref> Beyond the hammer and the scalpel: selective circuit control for the epilepsies #MMPMID25710834 Krook-Magnuson E; Soltesz I Nat Neurosci 2015[Mar]; 18 (3): 331-8 PMID25710834show ga Current treatment options for epilepsy are inadequate as too many patients suffer from uncontrolled seizures and from negative side effects of treatment. Along with major challenges in treatment, scientific understanding of epilepsy is also incomplete, with key questions in epilepsy research remaining unanswered. The major benefit of optogenetic and designer receptor technology is the unprecedented and much needed specificity they provide, allowing spatial, temporal, and cell-type selective modulation of neuronal circuits. Equipped with such tools, it is now possible to begin to address some of the fundamental unanswered questions in epilepsy, to dissect epileptic neuronal circuits, and to develop new intervention strategies. Such specificity of intervention also has the potential for direct therapeutic benefits, allowing healthy tissue and network functions to continue unaffected. In this Perspective, we discuss promising uses of these technologies for the study of seizures and epilepsy, as well as potential use of these strategies for clinical therapies. äBeyond the hammer and the scalpel: selective circuit control for the e(epmc).pdf DeepDyve Pubget Overpricing