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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Prev+Med 2015 ; 48 (3): 241-52 Nephropedia Template TP
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Total and Cause-Specific Mortality of U S Nurses Working Rotating Night Shifts #MMPMID25576495
Gu F; Han J; Laden F; Pan A; Caporaso NE; Stampfer MJ; Kawachi I; Rexrode KM; Willett WC; Hankinson SE; Speizer F; Schernhammer ES
Am J Prev Med 2015[Mar]; 48 (3): 241-52 PMID25576495show ga
Background: Rotating night shift work imposes circadian strain and is linked to the risk of several chronic diseases. Purpose: To examine associations between rotating night shift work and all-cause, cardiovascular disease (CVD), and cancer mortality in a prospective cohort study of 74,862 registered U.S. nurses from the Nurses? Health Study. Methods: Lifetime rotating night shift work (defined as ?3 nights/month) information was collected in 1988. During 22 years (1988?2010) of follow-up, 14,181 deaths were documented, including 3,062 CVD and 5,413 cancer deaths. Cox proportional hazards models (2013) estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs. Results: All-cause and CVD mortality were significantly increased among women with ?5 years of rotating night shift work, compared to women who never worked night shifts. Specifically, for women with 6?14 and ?15 years of rotating night shift work, the HRs were 1.11 (95% CI=1.06, 1.17) and 1.11 (95% CI=1.05, 1.18) for all-cause mortality and 1.19 (95% CI=1.07, 1.33) and 1.23 (95% CI=1.09, 1.38) for CVD mortality. There was no association between rotating night shift work and all-cancer mortality (HR?15years=1.08, 95% CI=0.89, 1.19) or any other cancer, with the exception of lung cancer (HR?15years=1.25, 95% CI=1.04, 1.51). Conclusions: Women working rotating night shifts for ?5 five years have a modest increase in all-cause and CVD mortality; those working ?15 years of rotating night shift work have a modest increase in lung cancer mortality. These results add to prior evidence of a potentially detrimental effect of rotating night shift work on health and longevity.