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2015 ; 74
(ä): 65-70
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Aggregator: a machine learning approach to identifying MEDLINE articles that
derive from the same underlying clinical trial
#MMPMID25461812
Shao W
; Adams CE
; Cohen AM
; Davis JM
; McDonagh MS
; Thakurta S
; Yu PS
; Smalheiser NR
Methods
2015[Mar]; 74
(ä): 65-70
PMID25461812
show ga
OBJECTIVE: It is important to identify separate publications that report outcomes
from the same underlying clinical trial, in order to avoid over-counting these as
independent pieces of evidence. METHODS: We created positive and negative
training sets (comprised of pairs of articles reporting on the same condition and
intervention) that were, or were not, linked to the same clinicaltrials.gov trial
registry number. Features were extracted from MEDLINE and PubMed metadata;
pairwise similarity scores were modeled using logistic regression. RESULTS:
Article pairs from the same trial were identified with high accuracy (F1
score=0.843). We also created a clustering tool, Aggregator, that takes as input
a PubMed user query for RCTs on a given topic, and returns article clusters
predicted to arise from the same clinical trial. DISCUSSION: Although painstaking
examination of full-text may be needed to be conclusive, metadata are
surprisingly accurate in predicting when two articles derive from the same
underlying clinical trial.
|*Machine Learning
[MESH]
|Clinical Trials as Topic/*statistics & numerical data
[MESH]