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10.1016/j.cellsig.2015.01.010 http://scihub22266oqcxt.onion/10.1016/j.cellsig.2015.01.010 C4339503!4339503 !25619567     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25619567 &cmd=llinks): Failed to open stream: HTTP request failed! 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Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis |pdf=|usr=}}{{25619567 }} gab.com Text Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis JO: Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=25619567 #FOAvip Dual-specificity phosphatase 2 (Dusp2; also called phosphatase of activated cells 1, PAC1) is highly expressed in activated immune cells. We examined whether a potential inhibitor of Dusp2, salubrinal, prevents inflammatory cytokine expression in immune cells and arthritic responses in a mouse model of anti-collagen antibody-induced arthritis (CAIA). Salubrinal is a synthetic chemical that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2?). In this study, we examined the effects of salubrinal on expression of inflammation linked genes as well as a family of DUSP genes using genome-wide microarrays, qPCR, and RNA interference. We also evaluated the effects of salubrinal on arthritic responses in CAIA mice using clinical and histological scores. The results revealed that salubrinal decreased inflammatory gene expression in macrophages, T lymphocytes, and mast cells. Dusp2 was suppressed by salubrinal in LPS-activated macrophages as well as PMA/ionomycin-activated T lymphocytes and mast cells. Furthermore, a partial silencing of Dusp2 downregulated IL1? and Cox2, and the inflammatory signs of CAIA mice were significantly suppressed by salubrinal. Collectively, this study presents a novel therapeutic possibility of salubrinal for inflammatory arthritis such as RA through inhibition of Dusp2. Twit Text FOAVip Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis ????Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=25619567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25619567 #FOAvip English Wikipedia <ref>{{Cite pmid|25619567 }}</ref> Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis #MMPMID25619567 Hamamura K ; Nishimura A ; Chen A ; Takigawa S ; Sudo A ; Yokota H Cell Signal 2015[Apr]; 27 (4 ): 828-35 PMID25619567 show ga Dual-specificity phosphatase 2 (Dusp2; also called phosphatase of activated cells 1, PAC1) is highly expressed in activated immune cells. We examined whether a potential inhibitor of Dusp2, salubrinal, prevents inflammatory cytokine expression in immune cells and arthritic responses in a mouse model of anti-collagen antibody-induced arthritis (CAIA). Salubrinal is a synthetic chemical that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2?). In this study, we examined the effects of salubrinal on expression of inflammation linked genes as well as a family of DUSP genes using genome-wide microarrays, qPCR, and RNA interference. We also evaluated the effects of salubrinal on arthritic responses in CAIA mice using clinical and histological scores. The results revealed that salubrinal decreased inflammatory gene expression in macrophages, T lymphocytes, and mast cells. Dusp2 was suppressed by salubrinal in LPS-activated macrophages as well as PMA/ionomycin-activated T lymphocytes and mast cells. Furthermore, a partial silencing of Dusp2 downregulated IL1? and Cox2, and the inflammatory signs of CAIA mice were significantly suppressed by salubrinal. Collectively, this study presents a novel therapeutic possibility of salubrinal for inflammatory arthritis such as RA through inhibition of Dusp2. |Animals [MESH] |Anti-Inflammatory Agents/*therapeutic use [MESH] |Arthritis, Experimental/*drug therapy/genetics/immunology/pathology [MESH] |Cell Line [MESH] |Cinnamates/*therapeutic use [MESH] |Cytokines/genetics/immunology [MESH] |Dual Specificity Phosphatase 2/*antagonists & inhibitors/genetics/immunology [MESH] |Female [MESH] |Gene Expression Regulation/drug effects [MESH] |Inflammation/drug therapy/genetics/immunology/pathology [MESH] |Interleukin-1beta/genetics/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |RNA Interference [MESH]Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in an(epmc).pdf DeepDyve Pubget Overpricing