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10.1016/j.preteyeres.2014.11.005 http://scihub22266oqcxt.onion/10.1016/j.preteyeres.2014.11.005 C4339497!4339497!25486088     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25486088&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prog+Retin+Eye+Res 2015 ; ä (ä): 1-29 Nephropedia Template TP {{tp|p=25486088|t=2015. Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy |pdf=|usr=}}{{25486088}} gab.com Text Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy JO: Prog Retin Eye Res http://www.kidney.de/pget.php?&tw=1&pmid=25486088 #FOAvip Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies. Twit Text FOAVip Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy ????Prog Retin Eye Res http://www.kidney.de/pget.php?&tw=1&pmid=25486088 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25486088 #FOAvip English Wikipedia <ref>{{Cite pmid|25486088}}</ref> Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy #MMPMID25486088 Whitmore S; Sohn EH; Chirco KR; Drack AV; Stone EM; Tucker BA; Mullins RF Prog Retin Eye Res 2015[Mar]; ä (ä): 1-29 PMID25486088show ga Age-related macular degeneration (AMD) is a common and devastating disease that can result in severe visual dysfunction. Over the last decade, great progress has been made in identifying genetic variants that contribute to AMD, many of which lie in genes involved in the complement cascade. In this review we discuss the significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris. We review the clinical, histological and biochemical data that indicate that vascular loss in the choroid occurs very early in the pathogenesis of AMD, and discuss the potential impact of vascular dropout on the retinal pigment epithelium, Bruch's membrane and the photoreceptor cells. Finally, we present a hypothesis for the pathogenesis of early AMD and consider the implications of this model on the development of new therapies. äComplement activation and choriocapillaris loss in early AMD: Implicat(epmc).pdf DeepDyve Pubget Overpricing