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10.1111/cns.12354 http://scihub22266oqcxt.onion/10.1111/cns.12354 C4339490!4339490!25438992     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       CNS+Neurosci+Ther 2015 ; 21 (3): 252-61 Nephropedia Template TP {{tp|p=25438992|t=2015. Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells |pdf=|usr=}}{{25438992}} gab.com Text Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells JO: CNS Neurosci Ther http://www.kidney.de/pget.php?&tw=1&pmid=25438992 #FOAvip Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the underlying mechanisms of the unlimited proliferation and progressive local invasion are still poorly understood, and no effective treatment has been developed for GBM patients. Aims: We determine the role of TRPM7 channels in the growth, migration, and infiltration of malignant glioma cells. Methods: Using a combination of RT?PCR, Western blot, and patch?clamp techniques, we demonstrated the expression of functional TRPM7 channels of A172 cells, a human glioma cell line, as well as in human glioma tissues. Furthermore, we evaluated the role of TRPM7 in growth, migration, and infiltration of A172 cells with MTT and transwell migration and invasion assays. Results: We showed the expression of functional TRPM7 channels in both A172 cells and human glioma tissues. Suppression of TRPM7 expression with TRPM7?siRNA dramatically reduced the proliferation, migration, and invasion of A172 cells. Pharmacological inhibition of TRPM7 channel with 2?aminoethoxydiphenyl borate (2?APB) showed a similar effect as TRPM7?siRNA. Conclusion: We demonstrate that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells. TRPM7 channel may represent a novel and promising target for therapeutic intervention of malignant glioma. Twit Text FOAVip Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells ????CNS Neurosci Ther http://www.kidney.de/pget.php?&tw=1&pmid=25438992 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25438992 #FOAvip English Wikipedia <ref>{{Cite pmid|25438992}}</ref> Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells #MMPMID25438992 Leng T; Li M; Shen J; Liu M; Li X; Sun H; Branigan D; Zeng Z; Si H; Li J; Chen J; Xiong Z CNS Neurosci Ther 2015[Mar]; 21 (3): 252-61 PMID25438992show ga Background: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the underlying mechanisms of the unlimited proliferation and progressive local invasion are still poorly understood, and no effective treatment has been developed for GBM patients. Aims: We determine the role of TRPM7 channels in the growth, migration, and infiltration of malignant glioma cells. Methods: Using a combination of RT?PCR, Western blot, and patch?clamp techniques, we demonstrated the expression of functional TRPM7 channels of A172 cells, a human glioma cell line, as well as in human glioma tissues. Furthermore, we evaluated the role of TRPM7 in growth, migration, and infiltration of A172 cells with MTT and transwell migration and invasion assays. Results: We showed the expression of functional TRPM7 channels in both A172 cells and human glioma tissues. Suppression of TRPM7 expression with TRPM7?siRNA dramatically reduced the proliferation, migration, and invasion of A172 cells. Pharmacological inhibition of TRPM7 channel with 2?aminoethoxydiphenyl borate (2?APB) showed a similar effect as TRPM7?siRNA. Conclusion: We demonstrate that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells. TRPM7 channel may represent a novel and promising target for therapeutic intervention of malignant glioma. äSuppression of TRPM7 Inhibits Proliferation, Migration, and Invasion o(epmc).pdf DeepDyve Pubget Overpricing