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10.1111/imr.12254 http://scihub22266oqcxt.onion/10.1111/imr.12254 C4339231!4339231!25703563     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Rev 2015 ; 264 (1): 233-48 Nephropedia Template TP {{tp|p=25703563|t=2015. Trans-species communication in the Mycobacterium tuberculosis-infected macrophage |pdf=|usr=}}{{25703563}} gab.com Text Trans-species communication in the Mycobacterium tuberculosis-infected macrophage JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25703563 #FOAvip Much of the infection cycle of Mycobacterium tuberculosis (Mtb) is spent within its host cell, the macrophage. As a consequence of the chronic, enduring nature of the infection, this cell/cell interaction has become highly intimate, and the bacterium has evolved to detect, react to, and manipulate the evolving, immune-modulated phenotype of its host. In this review, we discuss the nature of the endosomal/lysosomal continuum, the characterization of the bacterium?s transcriptional responses during the infection cycle, and the dominant environmental cues that shape this response. We also discuss how the metabolism of both cells is modulated by the infection and the impact that this has on the progression of the granuloma. Finally, we detail how these transcriptional responses can be exploited to construct reporter bacterial strains to probe the temporal and spatial environmental shifts experienced by Mtb during the course of experimental infections. These reporter strains provide new insights into the fitness of Mtb under immune- and drug-mediated pressure. Twit Text FOAVip Trans-species communication in the Mycobacterium tuberculosis-infected macrophage ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25703563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25703563 #FOAvip English Wikipedia <ref>{{Cite pmid|25703563}}</ref> Trans-species communication in the Mycobacterium tuberculosis-infected macrophage #MMPMID25703563 Tan S; Russell DG Immunol Rev 2015[Mar]; 264 (1): 233-48 PMID25703563show ga Much of the infection cycle of Mycobacterium tuberculosis (Mtb) is spent within its host cell, the macrophage. As a consequence of the chronic, enduring nature of the infection, this cell/cell interaction has become highly intimate, and the bacterium has evolved to detect, react to, and manipulate the evolving, immune-modulated phenotype of its host. In this review, we discuss the nature of the endosomal/lysosomal continuum, the characterization of the bacterium?s transcriptional responses during the infection cycle, and the dominant environmental cues that shape this response. We also discuss how the metabolism of both cells is modulated by the infection and the impact that this has on the progression of the granuloma. Finally, we detail how these transcriptional responses can be exploited to construct reporter bacterial strains to probe the temporal and spatial environmental shifts experienced by Mtb during the course of experimental infections. These reporter strains provide new insights into the fitness of Mtb under immune- and drug-mediated pressure. äTrans-species communication in the Mycobacterium tuberculosis-infected(epmc).pdf DeepDyve Pubget Overpricing