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10.1111/imr.12267 http://scihub22266oqcxt.onion/10.1111/imr.12267 C4339208!4339208!25703570     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Rev 2015 ; 264 (1): 327-43 Nephropedia Template TP {{tp|p=25703570|t=2015. New insights into TB physiology suggest untapped therapeutic opportunities |pdf=|usr=}}{{25703570}} gab.com Text New insights into TB physiology suggest untapped therapeutic opportunities JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25703570 #FOAvip The current drug regimens used to treat tuberculosis are largely comprised of serendipitously discovered drugs that are combined based on clinical experience. Despite curing millions, these drug regimens are limited by the long course of therapy, the emergence of resistance, and permanent tissue damage. The last two decades have produced only a single new drug but have represented a renaissance in our understanding of the physiology of TB infection. The advent of mycobacterial genetics, sophisticated immunological methods, and imaging technologies has transformed our understanding of bacterial physiology as well as the contribution of the host response to disease outcome. Specific alterations in bacterial metabolism, heterogeneity in bacterial state, and drug penetration all limit the effectiveness of antimicrobial therapy. This review summarizes these new biological insights and discusses strategies to exploit them for the rational development of more effective therapeutics. Three general strategies are discussed. First, our emerging insight into bacterial physiology suggests new pathways that might be targeted to accelerate therapy. Second, we explore whether the concept of genetic synergy can be used to design effective combination therapies. Finally, we outline possible approaches to modulate the host response to accentuate antibiotic efficacy. These biology-driven strategies promise to produce more effective therapies. Twit Text FOAVip New insights into TB physiology suggest untapped therapeutic opportunities ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25703570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25703570 #FOAvip English Wikipedia <ref>{{Cite pmid|25703570}}</ref> New insights into TB physiology suggest untapped therapeutic opportunities #MMPMID25703570 Baer CE; Rubin EJ; Sassetti CM Immunol Rev 2015[Mar]; 264 (1): 327-43 PMID25703570show ga The current drug regimens used to treat tuberculosis are largely comprised of serendipitously discovered drugs that are combined based on clinical experience. Despite curing millions, these drug regimens are limited by the long course of therapy, the emergence of resistance, and permanent tissue damage. The last two decades have produced only a single new drug but have represented a renaissance in our understanding of the physiology of TB infection. The advent of mycobacterial genetics, sophisticated immunological methods, and imaging technologies has transformed our understanding of bacterial physiology as well as the contribution of the host response to disease outcome. Specific alterations in bacterial metabolism, heterogeneity in bacterial state, and drug penetration all limit the effectiveness of antimicrobial therapy. This review summarizes these new biological insights and discusses strategies to exploit them for the rational development of more effective therapeutics. Three general strategies are discussed. First, our emerging insight into bacterial physiology suggests new pathways that might be targeted to accelerate therapy. Second, we explore whether the concept of genetic synergy can be used to design effective combination therapies. Finally, we outline possible approaches to modulate the host response to accentuate antibiotic efficacy. These biology-driven strategies promise to produce more effective therapies. äNew insights into TB physiology suggest untapped therapeutic opportuni(epmc).pdf DeepDyve Pubget Overpricing