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10.1038/ncomms6676 http://scihub22266oqcxt.onion/10.1038/ncomms6676 C4338530!4338530!25435099     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25435099&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2014 ; 5 (ä): 5676 Nephropedia Template TP {{tp|p=25435099|t=2014. A chemo-centric view of human health and disease |pdf=|usr=}}{{25435099}} gab.com Text A chemo-centric view of human health and disease JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25435099 #FOAvip Efforts to compile the phenotypic effects of drugs and environmental chemicals offer the opportunity to adopt a chemo-centric view of human health that does not require detailed mechanistic information. Here, we consider thousands of chemicals and analyze the relationship of their structures with adverse and therapeutic responses. Our study includes molecules related to the etiology of 934 health threatening conditions and used to treat 835 diseases. We first identify chemical moieties that could be independently associated with each phenotypic effect. Using these fragments, we build accurate predictors for approximately 400 clinical phenotypes, finding many privileged and liable structures. Finally, we connect two diseases if they relate to similar chemical structures. The resulting networks of human conditions are able to predict disease comorbidities, as well as identifying potential drug side effects and opportunities for drug repositioning, and show a remarkable coincidence with clinical observations. Twit Text FOAVip A chemo-centric view of human health and disease ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25435099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25435099 #FOAvip English Wikipedia <ref>{{Cite pmid|25435099}}</ref> A chemo-centric view of human health and disease #MMPMID25435099 Duran-Frigola M; Rossell D; Aloy P Nat Commun 2014[]; 5 (ä): 5676 PMID25435099show ga Efforts to compile the phenotypic effects of drugs and environmental chemicals offer the opportunity to adopt a chemo-centric view of human health that does not require detailed mechanistic information. Here, we consider thousands of chemicals and analyze the relationship of their structures with adverse and therapeutic responses. Our study includes molecules related to the etiology of 934 health threatening conditions and used to treat 835 diseases. We first identify chemical moieties that could be independently associated with each phenotypic effect. Using these fragments, we build accurate predictors for approximately 400 clinical phenotypes, finding many privileged and liable structures. Finally, we connect two diseases if they relate to similar chemical structures. The resulting networks of human conditions are able to predict disease comorbidities, as well as identifying potential drug side effects and opportunities for drug repositioning, and show a remarkable coincidence with clinical observations. äA chemo-centric view of human health and disease (epmc).pdf DeepDyve Pubget Overpricing