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10.1016/j.mce.2015.01.015 http://scihub22266oqcxt.onion/10.1016/j.mce.2015.01.015 C4337804!4337804!25596548     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Endocrinol 2015 ; 403 (ä): 30-8 Nephropedia Template TP {{tp|p=25596548|t=2015. Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1 |pdf=|usr=}}{{25596548}} gab.com Text Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1 JO: Mol Cell Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25596548 #FOAvip While Notch signaling plays a critical role in the regulation of cartilage formation, its downstream targets are unknown. To address this we performed gain and losses of function experiments and demonstrate that Notch inhibition of chondrogenesis acts via up-regulation of the transcription factor Twist1. Upon Notch activation, murine limb bud mesenchymal progenitor cells in micromass culture displayed an inhibition of chondrogenesis. Twist1 was found to be exclusively expressed in mesenchymal progenitor cells at the onset stage of chondrogenesis during Notch activation. Inhibition of Notch signaling in these cells significantly reduced protein expression of Twist1. Furthermore, the inhibition effect of NICD1 on MPC chondrogenesis was markedly reduced by knocking down of Twist1. Constitutively active Notch signaling significantly enhanced Twist1 promoter activity; whereas mutation studies indicated that a putative NICD/RBPjK binding element in the promoter region is required for the Notch-responsiveness of the Twist1 promoter. Finally, chromatin immunoprecipitation assays further confirmed that the Notch intracellular domain influences Twist1 by directly binding to the Twist1 promoter. These data provide a novel insight into understanding the molecular mechanisms behind Notch inhibition of the onset of chondrogenesis. Twit Text FOAVip Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1 ????Mol Cell Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25596548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25596548 #FOAvip English Wikipedia <ref>{{Cite pmid|25596548}}</ref> Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1 #MMPMID25596548 Tian Y; Xu Y; Fu Q; Chang M; Wang Y; Shang X; Wan C; Marymont JV; Dong Y Mol Cell Endocrinol 2015[Mar]; 403 (ä): 30-8 PMID25596548show ga While Notch signaling plays a critical role in the regulation of cartilage formation, its downstream targets are unknown. To address this we performed gain and losses of function experiments and demonstrate that Notch inhibition of chondrogenesis acts via up-regulation of the transcription factor Twist1. Upon Notch activation, murine limb bud mesenchymal progenitor cells in micromass culture displayed an inhibition of chondrogenesis. Twist1 was found to be exclusively expressed in mesenchymal progenitor cells at the onset stage of chondrogenesis during Notch activation. Inhibition of Notch signaling in these cells significantly reduced protein expression of Twist1. Furthermore, the inhibition effect of NICD1 on MPC chondrogenesis was markedly reduced by knocking down of Twist1. Constitutively active Notch signaling significantly enhanced Twist1 promoter activity; whereas mutation studies indicated that a putative NICD/RBPjK binding element in the promoter region is required for the Notch-responsiveness of the Twist1 promoter. Finally, chromatin immunoprecipitation assays further confirmed that the Notch intracellular domain influences Twist1 by directly binding to the Twist1 promoter. These data provide a novel insight into understanding the molecular mechanisms behind Notch inhibition of the onset of chondrogenesis. äNotch inhibits chondrogenic differentiation of mesenchymal progenitor (epmc).pdf DeepDyve Pubget Overpricing