Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25302741
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Depletion of regulatory T cells in a hapten-induced inflammation model results in
prolonged and increased inflammation driven by T cells
#MMPMID25302741
Christensen AD
; Skov S
; Kvist PH
; Haase C
Clin Exp Immunol
2015[Mar]; 179
(3
): 485-99
PMID25302741
show ga
Regulatory T cells (Tregs ) are known to play an immunosuppressive role in the
response of contact hypersensitivity (CHS), but neither the dynamics of Tregs
during the CHS response nor the exaggerated inflammatory response after depletion
of Tregs has been characterized in detail. In this study we show that the number
of Tregs in the challenged tissue peak at the same time as the ear-swelling
reaches its maximum on day 1 after challenge, whereas the number of Tregs in the
draining lymph nodes peaks at day 2. As expected, depletion of Tregs by injection
of a monoclonal antibody to CD25 prior to sensitization led to a prolonged and
sustained inflammatory response which was dependent upon CD8 T cells, and
co-stimulatory blockade with cytotoxic T lymphocyte antigen-4-immunoglobulin
(CTLA-4-Ig) suppressed the exaggerated inflammation. In contrast, blockade of the
interleukin (IL)-10-receptor (IL-10R) did not further increase the exaggerated
inflammatory response in the Treg -depleted mice. In the absence of Tregs , the
response changed from a mainly acute reaction with heavy infiltration of
neutrophils to a sustained response with more chronic characteristics (fewer
neutrophils and dominated by macrophages). Furthermore, depletion of Tregs
enhanced the release of cytokines and chemokines locally in the inflamed ear and
augmented serum levels of the systemic inflammatory mediators serum amyloid (SAP)
and haptoglobin early in the response.
free
free
free
