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2015 ; 38
(3
): 371-80
Nephropedia Template TP
gab.com Text
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English Wikipedia
Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of
restless legs syndrome
#MMPMID25325464
Richards KC
; Bost JE
; Rogers VE
; Hutchison LC
; Beck CK
; Bliwise DL
; Kovach CR
; Cuellar N
; Allen RP
Sleep
2015[Mar]; 38
(3
): 371-80
PMID25325464
show ga
STUDY OBJECTIVES: Lack of a valid diagnostic measure of restless legs syndrome
(RLS) for persons with dementia, who do not have the cognitive ability to report
complex symptoms, impedes RLS treatment and research in this population. The aim
of this study was to determine the sensitivity and specificity of a combination
of indicators for identifying RLS that could eventually be used to diagnose RLS
in persons with dementia. DESIGN: 3-day, prospective instrument validation.
SETTING: Sleep laboratory. PARTICIPANTS: Cognitively intact, 107 with RLS, 105
without RLS. INTERVENTIONS: N/A. MEASUREMENTS: Serial 20-min observations with a
new measure, the Behavioral Indicators Test-Restless Legs (BIT-RL); leg movements
with 3 nights of the Periodic Activity Monitor-Restless Legs (PAM-RL); ferritin;
sleep history; clinical data; polysomnography; Hopkins Telephone Diagnostic
Interview of RLS Symptoms. RESULTS: The best-fitting diagnostic model for
identifying RLS included previous history of iron deficiency (odds ratio [OR]
7.30), leg discomfort (OR 6.47), daytime fatigue (OR 6.15), difficulty falling
asleep (OR 3.25), RLS family history (OR 2.60), BIT-RL (OR 1.49), and absence of
diabetes (OR 0.27), with sensitivity 78%, specificity 79%, and 77% correctly
classified. This model retained its predictive accuracy even with co-morbid sleep
apnea. CONCLUSIONS: When compared to those without RLS, persons with RLS have
observable behaviors, such as rubbing the legs, that differentiate them, but the
behaviors have no circadian and activity-related variability. The final model of
clinical and sleep historical data and observation for RLS behaviors using the
BIT-RL had good diagnostic accuracy.
|*Behavior
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Dementia/*complications/psychology
[MESH]
|Female
[MESH]
|Ferritins/*blood
[MESH]
|Humans
[MESH]
|Leg/*physiopathology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Movement
[MESH]
|Polysomnography
[MESH]
|Prospective Studies
[MESH]
|Restless Legs Syndrome/blood/complications/*diagnosis/*physiopathology
[MESH]
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