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10.1007/s00109-014-1216-4 http://scihub22266oqcxt.onion/10.1007/s00109-014-1216-4 C4334731!4334731!25391250     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2015 ; 93 (3): 327-42 Nephropedia Template TP {{tp|p=25391250|t=2015. Peroxisome proliferator-activated receptor ? inhibits pulmonary hypertension targeting store-operated calcium entry |pdf=|usr=}}{{25391250}} gab.com Text Peroxisome proliferator-activated receptor inhibits pulmonary hypertension targeting store-operated calcium entry JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25391250 #FOAvip In this study, we investigated the role of peroxisome proliferator-activated receptor ? (PPAR?) on store-operated calcium entry (SOCE) and expression of the main store-operated calcium channels (SOCCs) components, canonical transient receptor potential (TRPC) in chronic hypoxia (CH) and monocrotaline (MCT)-induced PH rat models. siRNA knockdown and adenoviral overexpression strategies were constructed for both loss-of-function and gain-of-function experiments. PPAR? agonist rosiglitazone attenuates the pathogenesis of both CHPH and MCT-PH, suppresses Hif-1?, TRPC1, TRPC6 expression in the distal pulmonary artery (PA) and SOCE in freshly isolated rat distal pulmonary arterial smooth muscle cells (PASMCs). By comprehensive use of knockdown and overexpression studies, bioinformatically analysis of the TRPC gene promoter and luciferase reporter assay, we demonstrated that PPAR? exerts roles of anti-proliferation, anti-migration, and pro-apoptosis in PASMCs, likely by inhibiting the elevated SOCE and TRPC expression. These effects were inhibited under the conditions of hypoxia or Hif-1? accumulation. We also found that under hypoxia, accumulated Hif-1? protein acts as upstream of suppressed PPAR? level, however, targeted PPAR? rescue acts negative feedback on suppressing Hif-1? level and Hif-1? mediated signaling pathway. PPAR? inhibits PH by targeting SOCE and TRPC via inhibiting Hif-1? expression and signaling transduction. Twit Text FOAVip Peroxisome proliferator-activated receptor inhibits pulmonary hypertension targeting store-operated calcium entry ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25391250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25391250 #FOAvip English Wikipedia <ref>{{Cite pmid|25391250}}</ref> Peroxisome proliferator-activated receptor ? inhibits pulmonary hypertension targeting store-operated calcium entry #MMPMID25391250 Wang Y; Lu W; Yang K; Wang Y; Zhang J; Jia J; Yun X; Tian L; Chen Y; Jiang Q; Zhang B; Chen X; Wang J J Mol Med (Berl) 2015[Mar]; 93 (3): 327-42 PMID25391250show ga In this study, we investigated the role of peroxisome proliferator-activated receptor ? (PPAR?) on store-operated calcium entry (SOCE) and expression of the main store-operated calcium channels (SOCCs) components, canonical transient receptor potential (TRPC) in chronic hypoxia (CH) and monocrotaline (MCT)-induced PH rat models. siRNA knockdown and adenoviral overexpression strategies were constructed for both loss-of-function and gain-of-function experiments. PPAR? agonist rosiglitazone attenuates the pathogenesis of both CHPH and MCT-PH, suppresses Hif-1?, TRPC1, TRPC6 expression in the distal pulmonary artery (PA) and SOCE in freshly isolated rat distal pulmonary arterial smooth muscle cells (PASMCs). By comprehensive use of knockdown and overexpression studies, bioinformatically analysis of the TRPC gene promoter and luciferase reporter assay, we demonstrated that PPAR? exerts roles of anti-proliferation, anti-migration, and pro-apoptosis in PASMCs, likely by inhibiting the elevated SOCE and TRPC expression. These effects were inhibited under the conditions of hypoxia or Hif-1? accumulation. We also found that under hypoxia, accumulated Hif-1? protein acts as upstream of suppressed PPAR? level, however, targeted PPAR? rescue acts negative feedback on suppressing Hif-1? level and Hif-1? mediated signaling pathway. PPAR? inhibits PH by targeting SOCE and TRPC via inhibiting Hif-1? expression and signaling transduction. äPeroxisome proliferator-activated receptor ? inhibits pulmonary hypert(epmc).pdf DeepDyve Pubget Overpricing