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10.1007/s00109-015-1254-6 http://scihub22266oqcxt.onion/10.1007/s00109-015-1254-6 C4334711!4334711!25609139     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25609139&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Mol+Med+(Berl) 2015 ; 93 (3): 253-62 Nephropedia Template TP {{tp|p=25609139|t=2015. Mitophagy and heart failure |pdf=|usr=}}{{25609139}} gab.com Text Mitophagy and heart failure JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25609139 #FOAvip Cardiac mitochondria are responsible for generating energy in the form of ATP through oxidative phosphorylation and are crucial for cardiac function. Mitochondrial dysfunction is a major contributor to loss of myocytes and development of heart failure. Myocytes have quality control mechanisms in place to ensure a network of functional mitochondria. Damaged mitochondria are degraded by a process called mitochondrial autophagy, or mitophagy, where the organelle is engulfed by an autophagosome and subsequently delivered to a lysosome for degradation. Evidence suggests that mitophagy is important for cellular homeostasis, and reduced mitophagy leads to inadequate removal of dysfunctional mitochondria. In this review, we discuss the regulation of mitophagy and the emerging evidence of the cardioprotective role of mitophagy. We also address the prospect of therapeutically targeting mitophagy to treat patients with cardiovascular disease. Twit Text FOAVip Mitophagy and heart failure ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25609139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25609139 #FOAvip English Wikipedia <ref>{{Cite pmid|25609139}}</ref> Mitophagy and heart failure #MMPMID25609139 Shires SE; Gustafsson ÅB J Mol Med (Berl) 2015[Mar]; 93 (3): 253-62 PMID25609139show ga Cardiac mitochondria are responsible for generating energy in the form of ATP through oxidative phosphorylation and are crucial for cardiac function. Mitochondrial dysfunction is a major contributor to loss of myocytes and development of heart failure. Myocytes have quality control mechanisms in place to ensure a network of functional mitochondria. Damaged mitochondria are degraded by a process called mitochondrial autophagy, or mitophagy, where the organelle is engulfed by an autophagosome and subsequently delivered to a lysosome for degradation. Evidence suggests that mitophagy is important for cellular homeostasis, and reduced mitophagy leads to inadequate removal of dysfunctional mitochondria. In this review, we discuss the regulation of mitophagy and the emerging evidence of the cardioprotective role of mitophagy. We also address the prospect of therapeutically targeting mitophagy to treat patients with cardiovascular disease. äMitophagy and heart failure (epmc).pdf DeepDyve Pubget Overpricing