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10.1002/bies.201400177 http://scihub22266oqcxt.onion/10.1002/bies.201400177 C4334689!4334689 !25640595     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25640595 &cmd=llinks): Failed to open stream: HTTP request failed! 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Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms |pdf=|usr=}}{{25640595 }} gab.com Text Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25640595 #FOAvip Numerous accessory factors modulate RNA polymerase response to regulatory signals and cellular cues and establish communications with co-transcriptional RNA processing. Transcription regulators are astonishingly diverse, with similar mechanisms arising via convergent evolution. NusG/Spt5 elongation factors comprise the only universally conserved and ancient family of regulators. They bind to the conserved clamp helices domain of RNA polymerase, which also interacts with non-homologous initiation factors in all domains of life, and reach across the DNA channel to form processivity clamps that enable uninterrupted RNA chain synthesis. In addition to this ubiquitous function, NusG homologs exert diverse, and sometimes opposite, effects on gene expression by competing with each other and other regulators for binding to the clamp helices and by recruiting auxiliary factors that facilitate termination, antitermination, splicing, translation, etc. This surprisingly diverse range of activities and the underlying unprecedented structural changes make studies of these "transformer" proteins both challenging and rewarding. Twit Text FOAVip Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25640595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25640595 #FOAvip English Wikipedia <ref>{{Cite pmid|25640595 }}</ref> Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms #MMPMID25640595 NandyMazumdar M ; Artsimovitch I Bioessays 2015[Mar]; 37 (3 ): 324-34 PMID25640595 show ga Numerous accessory factors modulate RNA polymerase response to regulatory signals and cellular cues and establish communications with co-transcriptional RNA processing. Transcription regulators are astonishingly diverse, with similar mechanisms arising via convergent evolution. NusG/Spt5 elongation factors comprise the only universally conserved and ancient family of regulators. They bind to the conserved clamp helices domain of RNA polymerase, which also interacts with non-homologous initiation factors in all domains of life, and reach across the DNA channel to form processivity clamps that enable uninterrupted RNA chain synthesis. In addition to this ubiquitous function, NusG homologs exert diverse, and sometimes opposite, effects on gene expression by competing with each other and other regulators for binding to the clamp helices and by recruiting auxiliary factors that facilitate termination, antitermination, splicing, translation, etc. This surprisingly diverse range of activities and the underlying unprecedented structural changes make studies of these "transformer" proteins both challenging and rewarding. |Amino Acid Sequence [MESH] |Escherichia coli Proteins/chemistry/*physiology [MESH] |Gene Expression Regulation, Bacterial [MESH] |Humans [MESH] |Models, Molecular [MESH] |Molecular Sequence Data [MESH] |Peptide Elongation Factors/chemistry/*physiology [MESH] |Protein Binding [MESH] |Protein Conformation [MESH]Ubiquitous transcription factors display structural plasticity and div(epmc).pdf DeepDyve Pubget Overpricing