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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Viral+Immunol 2015 ; 28 (2): 93-100 Nephropedia Template TP
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Levels of Interleukin-35 and Its Relationship with Regulatory T-Cells in Chronic Hepatitis B Patients #MMPMID25494369
Shi Yy; Dai Mj; Wu Gp; Zhou Pp; Fang Y; Yan Xb
Viral Immunol 2015[Mar]; 28 (2): 93-100 PMID25494369show ga
Interleukin-35 is a novel inhibition cytokine secreted by CD4+CD25+ regulatory T-cells (Treg) in murine. However, it is disputed whether IL-35 could be secreted by Treg cells in humans. In this study, the levels of IL-35 were detected, and its relationship with regulatory T-cells in chronic hepatitis B (CHB) patients was investigated. It was shown that the levels of IL-35 in CHB patients were higher than those in normal controls, and the levels increased gradually, accompanied with the severe liver inflammation and necrosis and poor synthesis function. Treg cells may secrete IL-35, whose levels would become higher, accompanied by a longer activated time. Thus, IL-35 as a cytokine secreted by Treg cells may accelerate liver inflammation and necrosis, and inhibit the synthesis function.