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2015 ; 28
(2
): 93-100
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Levels of interleukin-35 and its relationship with regulatory T-cells in chronic
hepatitis B patients
#MMPMID25494369
Shi YY
; Dai MJ
; Wu GP
; Zhou PP
; Fang Y
; Yan XB
Viral Immunol
2015[Mar]; 28
(2
): 93-100
PMID25494369
show ga
Interleukin-35 is a novel inhibition cytokine secreted by CD4+CD25+ regulatory
T-cells (Treg) in murine. However, it is disputed whether IL-35 could be secreted
by Treg cells in humans. In this study, the levels of IL-35 were detected, and
its relationship with regulatory T-cells in chronic hepatitis B (CHB) patients
was investigated. It was shown that the levels of IL-35 in CHB patients were
higher than those in normal controls, and the levels increased gradually,
accompanied with the severe liver inflammation and necrosis and poor synthesis
function. Treg cells may secrete IL-35, whose levels would become higher,
accompanied by a longer activated time. Thus, IL-35 as a cytokine secreted by
Treg cells may accelerate liver inflammation and necrosis, and inhibit the
synthesis function.