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10.1021/mp500436p http://scihub22266oqcxt.onion/10.1021/mp500436p C4334274!4334274!25188586     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Pharm 2014 ; 11 (10): 3766-71 Nephropedia Template TP {{tp|p=25188586|t=2014. Shape-Controlled Paclitaxel Nanoparticles with Multiple Morphologies: Rod-Shaped, Worm-Like, Spherical, and Fingerprint-Like |pdf=|usr=}}{{25188586}} gab.com Text Shape-Controlled Paclitaxel Nanoparticles with Multiple Morphologies: Rod-Shaped, Worm-Like, Spherical, and Fingerprint-Like JO: Mol Pharm http://www.kidney.de/pget.php?&tw=1&pmid=25188586 #FOAvip Although many nanocarriers have been developed to encapsulate paclitaxel (PTX), the drug loading and circulation time in vivo always are not ideal because of its rigid ?brickdust? molecular structure. People usually concentrate their attention on the spherical nanocarriers, here paclitaxel nanoparticles with different geometries were established through the chemical modification of PTX, nanoprecipitation, and core-matched cargos. Previously we have developed rod-shape paclitaxel nanocrystals using block copolymer, pluronic F127. Unfortunately, the pharmacokinetic (PK) profile of PTX nanocrystals is very poor. However, when PTX was replaced by its prodrug, the geometry of the nanoparticles changed from rod-shaped to worm-like. The worm-like nanoparticles can be further changed to spherical nanoparticles using the nanoprecipitation method, and changed to fingerprint-like nanoparticles upon the addition of the core-matched PTX. The nanoparticles with nonspherical morphologies, including worm-like nanoparticles and fingerprint-like nanoparticles, offer significant advantages in regards to key PK parameters in vivo. More important, in this report the application of the core-matching technology in creating a core-matched environment capable of controlling the in vivo PK of paclitaxel was demonstrated, and it revealed a novel technique platform to construct nanoparticles and improve the poor PK profiles of the drugs. Twit Text FOAVip Shape-Controlled Paclitaxel Nanoparticles with Multiple Morphologies: Rod-Shaped, Worm-Like, Spherical, and Fingerprint-Like ????Mol Pharm http://www.kidney.de/pget.php?&tw=1&pmid=25188586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25188586 #FOAvip English Wikipedia <ref>{{Cite pmid|25188586}}</ref> Shape-Controlled Paclitaxel Nanoparticles with Multiple Morphologies: Rod-Shaped, Worm-Like, Spherical, and Fingerprint-Like #MMPMID25188586 Wang Y; Wang D; Fu Q; Liu D; Ma Y; Racette K; He Z; Liu F Mol Pharm 2014[Oct]; 11 (10): 3766-71 PMID25188586show ga Although many nanocarriers have been developed to encapsulate paclitaxel (PTX), the drug loading and circulation time in vivo always are not ideal because of its rigid ?brickdust? molecular structure. People usually concentrate their attention on the spherical nanocarriers, here paclitaxel nanoparticles with different geometries were established through the chemical modification of PTX, nanoprecipitation, and core-matched cargos. Previously we have developed rod-shape paclitaxel nanocrystals using block copolymer, pluronic F127. Unfortunately, the pharmacokinetic (PK) profile of PTX nanocrystals is very poor. However, when PTX was replaced by its prodrug, the geometry of the nanoparticles changed from rod-shaped to worm-like. The worm-like nanoparticles can be further changed to spherical nanoparticles using the nanoprecipitation method, and changed to fingerprint-like nanoparticles upon the addition of the core-matched PTX. The nanoparticles with nonspherical morphologies, including worm-like nanoparticles and fingerprint-like nanoparticles, offer significant advantages in regards to key PK parameters in vivo. More important, in this report the application of the core-matching technology in creating a core-matched environment capable of controlling the in vivo PK of paclitaxel was demonstrated, and it revealed a novel technique platform to construct nanoparticles and improve the poor PK profiles of the drugs. äShape-Controlled Paclitaxel Nanoparticles with Multiple Morphologies: (epmc).pdf DeepDyve Pubget Overpricing