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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Behav+Neurosci+Rep 2014 ; 1 (3): 134-43 Nephropedia Template TP
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Looking beyond Fear and Extinction Learning: Considering Novel Treatment Targets for Anxiety #MMPMID25705579
Britton JC; Evans TC; Hernandez MV
Curr Behav Neurosci Rep 2014[Sep]; 1 (3): 134-43 PMID25705579show ga
Fear conditioning studies provide valuable insight into how fears are learned and extinguished. Previous work focuses on fear and extinction learning to understand and treat anxiety disorders. However, a cascade of cognitive processes that extend beyond learning may also yield therapeutic targets for anxiety disorders. Throughout this review, we will discuss recent findings of fear generalization, memory consolidation, and reconsolidation. Factors related to effectiveness, efficiency and durability of extinction-based treatments will be addressed. Moreover, adolescence may be a key developmental stage when threat-related perturbations emerge; therefore, targeting interventions during adolescence when these nascent processes are more malleable may alter the trajectory of anxiety disorders.