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10.1021/ja501988b http://scihub22266oqcxt.onion/10.1021/ja501988b C4333595!4333595!24689802     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2014 ; 136 (16): 6123-35 Nephropedia Template TP {{tp|p=24689802|t=2014. Redox-Neutral ?-Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism |pdf=|usr=}}{{24689802}} gab.com Text Redox-Neutral -Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24689802 #FOAvip Cyclic secondary amines and 2-hydroxybenzaldehydes or related ketones react to furnish benzo[e][1,3]oxazine structures in generally good yields. This overall redox-neutral amine ?-C?H functionalization features a combined reductive N-alkylation/oxidative ?-functionalization and is catalyzed by acetic acid. In contrast to previous reports, no external oxidants or metal catalysts are required. Reactions performed under modified conditions lead to an apparent reductive amination and the formation of o-hydroxybenzylamines in a process that involves the oxidation of a second equivalent of amine. A detailed computational study employing density functional theory compares different mechanistic pathways and is used to explain the observed experimental findings. Furthermore, these results also reveal the origin of the catalytic efficiency of acetic acid in these transformations. Twit Text FOAVip Redox-Neutral -Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24689802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24689802 #FOAvip English Wikipedia <ref>{{Cite pmid|24689802}}</ref> Redox-Neutral ?-Oxygenation of Amines: Reaction Development and Elucidation of the Mechanism #MMPMID24689802 Richers M; Breugst M; Platonova AY; Ullrich A; Dieckmann A; Houk KN; Seidel D J Am Chem Soc 2014[Apr]; 136 (16): 6123-35 PMID24689802show ga Cyclic secondary amines and 2-hydroxybenzaldehydes or related ketones react to furnish benzo[e][1,3]oxazine structures in generally good yields. This overall redox-neutral amine ?-C?H functionalization features a combined reductive N-alkylation/oxidative ?-functionalization and is catalyzed by acetic acid. In contrast to previous reports, no external oxidants or metal catalysts are required. Reactions performed under modified conditions lead to an apparent reductive amination and the formation of o-hydroxybenzylamines in a process that involves the oxidation of a second equivalent of amine. A detailed computational study employing density functional theory compares different mechanistic pathways and is used to explain the observed experimental findings. Furthermore, these results also reveal the origin of the catalytic efficiency of acetic acid in these transformations. äRedox-Neutral ?-Oxygenation of Amines: Reaction Development and Elucid(epmc).pdf DeepDyve Pubget Overpricing