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10.1038/ni.3093 http://scihub22266oqcxt.onion/10.1038/ni.3093 C4333215!4333215!25621826     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (3): 318-25 Nephropedia Template TP {{tp|p=25621826|t=2015. LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 |pdf=|usr=}}{{25621826}} gab.com Text LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25621826 #FOAvip Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and de novo transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated TH1-specific lincRNA, was inversely correlated with MAF, a TH2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward TH2. We identified a long-distance interaction between linc-MAF-4 and MAF genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated MAF transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation. Twit Text FOAVip LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25621826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25621826 #FOAvip English Wikipedia <ref>{{Cite pmid|25621826}}</ref> LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 #MMPMID25621826 Ranzani V; Rossetti G; Panzeri I; Arrigoni A; Bonnal RJ; Curti S; Gruarin P; Provasi E; Sugliano E; Marconi M; De Francesco R; Geginat J; Bodega B; Abrignani S; Pagani M Nat Immunol 2015[Mar]; 16 (3): 318-25 PMID25621826show ga Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and de novo transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated TH1-specific lincRNA, was inversely correlated with MAF, a TH2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward TH2. We identified a long-distance interaction between linc-MAF-4 and MAF genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated MAF transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation. äLincRNA landscape in human lymphocytes highlights regulation of T cell(epmc).pdf DeepDyve Pubget Overpricing