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10.1158/1078-0432.CCR-14-0809 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-14-0809 C4333206!4333206 !25388163     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25388163 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Cancer+Res 2015 ; 21 (5 ): 955-61 Nephropedia Template TP {{tp|p=25388163 |t=2015. Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer |pdf=|usr=}}{{25388163 }} gab.com Text Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25388163 #FOAvip Over 100 years have passed since the first observation of the notched wing phenotype in Drosophila melanogaster, and significant progress has been made to characterize the role of the Notch receptor, its ligands, downstream targets, and cross-talk with other signaling pathways. The canonical Notch pathway with four Notch receptors (Notch1-4) and five ligands (DLL1, 3-4, Jagged 1-2) is an evolutionarily conserved cell signaling pathway that plays critical roles in cell-fate determination, differentiation, development, tissue patterning, cell proliferation, and death. In cancer, these roles have a critical impact on tumor behavior and response to therapy. Because the role of Notch remains tissue and context dependent, alterations within this pathway may lead to tumor suppressive or oncogenic phenotypes. Although no FDA-approved therapies currently exist for the Notch pathway, multiple therapeutics (e.g., demcizumab, tarextumab, GSI MK-0752, R04929097, and PF63084014) have been developed to target different aspects of this pathway for both hematologic and solid malignancies. Understanding the context-specific effects of the Notch pathway will be important for individualized therapies targeting this pathway. Twit Text FOAVip Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25388163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25388163 #FOAvip English Wikipedia <ref>{{Cite pmid|25388163 }}</ref> Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer #MMPMID25388163 Previs RA ; Coleman RL ; Harris AL ; Sood AK Clin Cancer Res 2015[Mar]; 21 (5 ): 955-61 PMID25388163 show ga Over 100 years have passed since the first observation of the notched wing phenotype in Drosophila melanogaster, and significant progress has been made to characterize the role of the Notch receptor, its ligands, downstream targets, and cross-talk with other signaling pathways. The canonical Notch pathway with four Notch receptors (Notch1-4) and five ligands (DLL1, 3-4, Jagged 1-2) is an evolutionarily conserved cell signaling pathway that plays critical roles in cell-fate determination, differentiation, development, tissue patterning, cell proliferation, and death. In cancer, these roles have a critical impact on tumor behavior and response to therapy. Because the role of Notch remains tissue and context dependent, alterations within this pathway may lead to tumor suppressive or oncogenic phenotypes. Although no FDA-approved therapies currently exist for the Notch pathway, multiple therapeutics (e.g., demcizumab, tarextumab, GSI MK-0752, R04929097, and PF63084014) have been developed to target different aspects of this pathway for both hematologic and solid malignancies. Understanding the context-specific effects of the Notch pathway will be important for individualized therapies targeting this pathway. |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology/therapeutic use [MESH] |Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MESH] |Drug Discovery [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Neoplasms/drug therapy/*metabolism [MESH] |Oncogene Proteins/metabolism [MESH] |Patient Selection [MESH] |Receptors, Notch/antagonists & inhibitors/*metabolism [MESH] |Translational Research, Biomedical [MESH]Molecular pathways: translational and therapeutic implications of the (epmc).pdf DeepDyve Pubget Overpricing