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10.1038/ni.3095 http://scihub22266oqcxt.onion/10.1038/ni.3095 C4333102!4333102!25642821     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (3): 296-305 Nephropedia Template TP {{tp|p=25642821|t=2015. Switched-memory B cells remodel B cell receptors within secondary germinal centers |pdf=|usr=}}{{25642821}} gab.com Text Switched-memory B cells remodel B cell receptors within secondary germinal centers JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25642821 #FOAvip Effective vaccines induce high-affinity memory B cells and durable antibody responses through accelerated mechanisms of natural selection. Secondary changes in antibody repertoires after vaccine boosts suggest progressive B cell receptor (BCR) re-diversification, but underlying mechanisms remain unresolved. Here integrated specificity and function of individual memory B cell progeny reveal ongoing evolution of polyclonal antibody specificities through germinal center (GC) specific transcriptional activity. At the clonal and sub-clonal levels, single cell expression of Cd83 and Pol? segregates the secondary GC transcriptional program into 4 stages that regulate divergent mechanisms of memory BCR evolution. These studies demonstrate that vaccine boosts re-activate a cyclic program of GC function in switched-memory B cells to remodel existing antibody specificities and enhance durable immune protection. Twit Text FOAVip Switched-memory B cells remodel B cell receptors within secondary germinal centers ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25642821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25642821 #FOAvip English Wikipedia <ref>{{Cite pmid|25642821}}</ref> Switched-memory B cells remodel B cell receptors within secondary germinal centers #MMPMID25642821 McHeyzer-Williams LJ; Milpied PJ; Okitsu SL; McHeyzer-Williams MG Nat Immunol 2015[Mar]; 16 (3): 296-305 PMID25642821show ga Effective vaccines induce high-affinity memory B cells and durable antibody responses through accelerated mechanisms of natural selection. Secondary changes in antibody repertoires after vaccine boosts suggest progressive B cell receptor (BCR) re-diversification, but underlying mechanisms remain unresolved. Here integrated specificity and function of individual memory B cell progeny reveal ongoing evolution of polyclonal antibody specificities through germinal center (GC) specific transcriptional activity. At the clonal and sub-clonal levels, single cell expression of Cd83 and Pol? segregates the secondary GC transcriptional program into 4 stages that regulate divergent mechanisms of memory BCR evolution. These studies demonstrate that vaccine boosts re-activate a cyclic program of GC function in switched-memory B cells to remodel existing antibody specificities and enhance durable immune protection. äSwitched-memory B cells remodel B cell receptors within secondary germ(epmc).pdf DeepDyve Pubget Overpricing