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10.1016/j.cellsig.2015.01.004 http://scihub22266oqcxt.onion/10.1016/j.cellsig.2015.01.004 C4333021!4333021!25582983     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Signal 2015 ; 27 (3): 487-97 Nephropedia Template TP {{tp|p=25582983|t=2015. Hedgehog signaling stimulates the conversion of cholesterol to steroids |pdf=|usr=}}{{25582983}} gab.com Text Hedgehog signaling stimulates the conversion of cholesterol to steroids JO: Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=25582983 #FOAvip Cholesterol modification of Hedgehog (Hh) ligands is fundamental for the activity of Hh signaling, and cholesterol biosynthesis is also required for intracellular Hh signaling transduction. Here, we investigated the roles and underlying mechanism of Hh signaling in metabolism of cholesterol. The main components of the Hh pathway are abundantly expressed in both human cytotrophoblasts and trophoblast-like cells. Activation of Hh signaling induces the conversion of cholesterol to progesterone (P4) and estradiol (E2) through up-regulating the expression of steroidogenic enzymes including P450 cholesterol side chain cleavage enzyme (P450scc), 3?-hydroxysteroid dehydrogenase type 1 (3?-HSD1), and aromatase. Moreover, inhibition of Hh signaling attenuates not only Hh-induced expression of steroidogenic enzymes but also the conversion of cholesterol to P4 and E2. Whereas Gli3 is required for Hh-induced P450scc expression, Gli2 mediates the induction of 3?-HSD1 and aromatase. Finally, in ovariectomized nude mice, systemic inhibition of Hh signaling by cyclopamine suppresses circulating P4 and E2 levels derived from a trophoblast-like choricarcinoma xenograft, and attenuates uterine response to P4 and E2. Together these results uncover a hitherto uncharacterized role of Hh signaling in metabolism of cholesterol. Twit Text FOAVip Hedgehog signaling stimulates the conversion of cholesterol to steroids ????Cell Signal http://www.kidney.de/pget.php?&tw=1&pmid=25582983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25582983 #FOAvip English Wikipedia <ref>{{Cite pmid|25582983}}</ref> Hedgehog signaling stimulates the conversion of cholesterol to steroids #MMPMID25582983 Tang C; Pan Y; Luo H; Xiong W; Zhu H; Ruan H; Wang J; Zou C; Tang L; Ikuchi T; Long F; Wu X Cell Signal 2015[Mar]; 27 (3): 487-97 PMID25582983show ga Cholesterol modification of Hedgehog (Hh) ligands is fundamental for the activity of Hh signaling, and cholesterol biosynthesis is also required for intracellular Hh signaling transduction. Here, we investigated the roles and underlying mechanism of Hh signaling in metabolism of cholesterol. The main components of the Hh pathway are abundantly expressed in both human cytotrophoblasts and trophoblast-like cells. Activation of Hh signaling induces the conversion of cholesterol to progesterone (P4) and estradiol (E2) through up-regulating the expression of steroidogenic enzymes including P450 cholesterol side chain cleavage enzyme (P450scc), 3?-hydroxysteroid dehydrogenase type 1 (3?-HSD1), and aromatase. Moreover, inhibition of Hh signaling attenuates not only Hh-induced expression of steroidogenic enzymes but also the conversion of cholesterol to P4 and E2. Whereas Gli3 is required for Hh-induced P450scc expression, Gli2 mediates the induction of 3?-HSD1 and aromatase. Finally, in ovariectomized nude mice, systemic inhibition of Hh signaling by cyclopamine suppresses circulating P4 and E2 levels derived from a trophoblast-like choricarcinoma xenograft, and attenuates uterine response to P4 and E2. Together these results uncover a hitherto uncharacterized role of Hh signaling in metabolism of cholesterol. äHedgehog signaling stimulates the conversion of cholesterol to steroid(epmc).pdf DeepDyve Pubget Overpricing