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10.4049/jimmunol.1401871 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401871 C4332405!4332405!25367120     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (12): 6005-15 Nephropedia Template TP {{tp|p=25367120|t=2014. Immature recent thymic emigrants are eliminated by complement1 |pdf=|usr=}}{{25367120}} gab.com Text Immature recent thymic emigrants are eliminated by complement1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25367120 #FOAvip Recent thymic emigrants (RTEs) must undergo phenotypic and functional maturation to become long-lived mature naïve T cells. In CD4-cre NKAP conditional knockout mice, NKAP-deficient RTEs fail to complete T cell maturation. Here, we demonstrate that NKAP-deficient immature RTEs do not undergo apoptosis, but are eliminated by complement. C3, C4 and C1q are bound to NKAP-deficient peripheral T cells, demonstrating activation of the classical arm of the complement pathway. As thymocytes mature and exit to the periphery, they increase sialic acid incorporation into cell surface glycans. This is essential to peripheral lymphocyte survival, as stripping sialic acid with neuraminidase leads to the binding of natural IgM and complement fixation. NKAP-deficient T cells have a defect in sialylation on cell surface glycans, leading to IgM recruitment. We demonstrate that the defect in sialylation is due to aberrant ?2,8-linked sialylation, and the expression of three genes (ST8sia1, ST8sia4 and ST8sia6) that mediate ?2,8 sialylation are down regulated in NKAP-defcient RTEs. The maturation of peripheral NKAP-deficient T cells is partially rescued in a C3-deficient environment. Thus, sialylation during T cell maturation is critical to protect immature RTEs from complement in the periphery. Twit Text FOAVip Immature recent thymic emigrants are eliminated by complement1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25367120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25367120 #FOAvip English Wikipedia <ref>{{Cite pmid|25367120}}</ref> Immature recent thymic emigrants are eliminated by complement1 #MMPMID25367120 Hsu FC; Shapiro MJ; Chen MW; McWilliams DC; Seaburg LM; Tangen SN; Shapiro VS J Immunol 2014[Dec]; 193 (12): 6005-15 PMID25367120show ga Recent thymic emigrants (RTEs) must undergo phenotypic and functional maturation to become long-lived mature naïve T cells. In CD4-cre NKAP conditional knockout mice, NKAP-deficient RTEs fail to complete T cell maturation. Here, we demonstrate that NKAP-deficient immature RTEs do not undergo apoptosis, but are eliminated by complement. C3, C4 and C1q are bound to NKAP-deficient peripheral T cells, demonstrating activation of the classical arm of the complement pathway. As thymocytes mature and exit to the periphery, they increase sialic acid incorporation into cell surface glycans. This is essential to peripheral lymphocyte survival, as stripping sialic acid with neuraminidase leads to the binding of natural IgM and complement fixation. NKAP-deficient T cells have a defect in sialylation on cell surface glycans, leading to IgM recruitment. We demonstrate that the defect in sialylation is due to aberrant ?2,8-linked sialylation, and the expression of three genes (ST8sia1, ST8sia4 and ST8sia6) that mediate ?2,8 sialylation are down regulated in NKAP-defcient RTEs. The maturation of peripheral NKAP-deficient T cells is partially rescued in a C3-deficient environment. Thus, sialylation during T cell maturation is critical to protect immature RTEs from complement in the periphery. äImmature recent thymic emigrants are eliminated by complement1 (epmc).pdf DeepDyve Pubget Overpricing