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Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Behav+Pharmacol 2014 ; 25 (7): 673-83 Nephropedia Template TP
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GABA Neural Signaling in the Latero-Anterior Hypothalamus Modulates Aggressive Behavior in Adolescent Anabolic/Androgenic Steroid-Treated Hamsters #MMPMID25171080
Morrison TR; Ricci LA; Melloni RH
Behav Pharmacol 2014[Oct]; 25 (7): 673-83 PMID25171080show ga
Male Syrian hamsters (Mesocricetus auratus) treated with anabolic/androgenic steroids (AAS) during adolescence (P27?P56) display highly escalated and mature forms of offensive aggression correlated with increased ?-aminobutyric acid (GABA) afferent development as well as decreased GABAA receptors in the latero-anterior hypothalamus (LAH) ? an area of convergence for developmental and neuroplastic changes that underlie offensive aggressive behaviors in hamsters. This study investigated whether microinfusion of a GABAA receptor agonist (muscimol; 0.01 ? 1.0 pM) or antagonist (bicuculline; 0.04 ? 4.0 pM) directly into the LAH modulate adolescent AAS-induced offensive aggression. Activation of LAH GABAA receptors enhanced adolescent AAS-induced offensive aggression, beginning at the 0.1pM dose, when compared with AAS-treated animals injected with saline into the LAH. Importantly, GABAA receptor agonism within the LAH significantly increased the frequency of belly/rear attacks, while simultaneously decreasing the frequency of frontal attacks. These data identify a neuroanatomical locus where GABAA receptor activation functions to enhance aggression in adolescent AAS-treated animals, while also promoting the display of mature forms of aggression and suppressing juvenile play behaviors.