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2014 ; 25
(7
): 673-83
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?-Aminobutyric acid neural signaling in the lateroanterior hypothalamus modulates
aggressive behavior in adolescent anabolic/androgenic steroid-treated hamsters
#MMPMID25171080
Morrison TR
; Ricci LA
; Melloni RH Jr
Behav Pharmacol
2014[Oct]; 25
(7
): 673-83
PMID25171080
show ga
Male Syrian hamsters (Mesocricetus auratus) treated with anabolic/androgenic
steroids (AAS) during adolescence (P27-P56) display highly escalated and mature
forms of offensive aggression correlated with increased ?-aminobutyric acid
(GABA) afferent development as well as decreased GABAA receptors in the
lateroanterior hypothalamus (LAH) - an area of convergence for developmental and
neuroplastic changes that underlie offensive aggressive behaviors in hamsters.
This study investigated whether microinfusion of a GABAA receptor agonist
(muscimol; 0.01-1.0?pmol/l) or antagonist (bicuculline; 0.04-4.0?pmol/l) directly
into the LAH modulate adolescent AAS-induced offensive aggression. Activation of
LAH GABAA receptors enhanced adolescent AAS-induced offensive aggression,
beginning at the 0.1?pmol/l dose, when compared with AAS-treated animals injected
with saline into the LAH. Importantly, GABAA receptor agonism within the LAH
significantly increased the frequency of belly/rear attacks, while simultaneously
decreasing the frequency of frontal attacks. These data identify a
neuroanatomical locus where GABAA receptor activation functions to enhance
aggression in adolescent AAS-treated animals, while also promoting the display of
mature forms of aggression and suppressing juvenile play behaviors.