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10.1021/jm500810s http://scihub22266oqcxt.onion/10.1021/jm500810s C4329993!4329993 !25349901     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25349901 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25349901 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Chem 2015 ; 58 (3 ): 1020-37 Nephropedia Template TP {{tp|p=25349901 |t=2015. Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications |pdf=|usr=}}{{25349901 }} gab.com Text Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25349901 #FOAvip Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic ?-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic ?-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets. Twit Text FOAVip Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=25349901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25349901 #FOAvip English Wikipedia <ref>{{Cite pmid|25349901 }}</ref> Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications #MMPMID25349901 Manandhar B ; Ahn JM J Med Chem 2015[Feb]; 58 (3 ): 1020-37 PMID25349901 show ga Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic ?-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic ?-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets. |*Glucagon-Like Peptide 1/metabolism/therapeutic use [MESH] |Animals [MESH] |Diabetes Mellitus/drug therapy/metabolism [MESH] |Humans [MESH] |Insulin-Secreting Cells/metabolism [MESH]Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibil(epmc).pdf DeepDyve Pubget Overpricing