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10.1097/PAS.0000000000000338

http://scihub22266oqcxt.onion/10.1097/PAS.0000000000000338
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C4326586!4326586!25353281
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suck abstract from ncbi


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pmid25353281      Am+J+Surg+Pathol 2015 ; 39 (3): 365-73
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  • Primary Renal Sclerosing Epithelioid Fibrosarcoma: Report of Two Cases with EWSR1-CREB3L1 Gene Fusion #MMPMID25353281
  • Argani P; Lewin JR; Edmonds P; Netto GJ; Prieto-Granada C; Zhang L; Jungbluth AA; Antonescu CR
  • Am J Surg Pathol 2015[Mar]; 39 (3): 365-73 PMID25353281show ga
  • We report the first two genetically confirmed cases of primary renal sclerosing epithelioid fibrosarcoma (SEF), occurring in a 17 year-old male and a 61 year-old female. In both cases, the tumors demonstrated the typical epithelioid clear cell morphology associated with extensive hyalinizing fibrosis, raising the differential diagnosis of solitary fibrous tumor, metanephric stromal tumor, and the sclerosing variant of clear cell sarcoma of the kidney. Both neoplasms demonstrated diffuse immunoreactivity for MUC4, a highly specific marker for SEF, and both demonstrated evidence of rearrangement of both the EWSR1 and CREB3L1 genes which have recently shown to be fused in this entity. Both neoplasms presented with metastatic disease. Primary renal SEF represents yet another translocation-associated sarcoma now shown to arise primarily in the kidney.
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