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10.1007/s12192-014-0542-3 http://scihub22266oqcxt.onion/10.1007/s12192-014-0542-3 C4326394!4326394 !25181965     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25181965 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stress+Chaperones 2015 ; 20 (2 ): 289-95 Nephropedia Template TP {{tp|p=25181965 |t=2015. Edaravone protects human peripheral blood lymphocytes from ?-irradiation-induced apoptosis and DNA damage |pdf=|usr=}}{{25181965 }} gab.com Text Edaravone protects human peripheral blood lymphocytes from -irradiation-induced apoptosis and DNA damage JO: Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=25181965 #FOAvip Radiation-induced cellular injury is attributed primarily to the harmful effects of free radicals, which play a key role in irradiation-induced apoptosis. In this study, we investigated the radioprotective efficacy of edaravone, a licensed clinical drug and a powerful free radical scavenger that has been tested against ?-irradiation-induced cellular damage in cultured human peripheral blood lymphocytes in studies of various diseases. Edaravone was pre-incubated with lymphocytes for 2 h prior to ?-irradiation. It was found that pretreatment with edaravone increased cell viability and inhibited generation of ?-radiation-induced reactive oxygen species (ROS) in lymphocytes exposed to 3 Gy ?-radiation. In addition, ?-radiation decreased antioxidant enzymatic activity, such as superoxide dismutase and glutathione peroxidase, as well as the level of reduced glutathione. Conversely, treatment with 100 ?M edaravone prior to irradiation improved antioxidant enzyme activity and increased reduced glutathione levels in irradiated lymphocytes. Importantly, we also report that edaravone reduced ?-irradiation-induced apoptosis through downregulation of Bax, upregulation of Bcl-2, and consequent reduction of the Bax:Bcl-2 ratio. The current study shows edaravone to be an effective radioprotector against ?-irradiation-induced cellular damage in lymphocytes in vitro. Finally, edaravone pretreatment significantly reduced DNA damage in ?-irradiated lymphocytes, as measured by comet assay (% tail DNA, tail length, tail moment, and olive tail moment) (p?<?0.05). Thus, the current study indicates that edaravone offers protection from radiation-induced cytogenetic alterations. Twit Text FOAVip Edaravone protects human peripheral blood lymphocytes from -irradiation-induced apoptosis and DNA damage ????Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=25181965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25181965 #FOAvip English Wikipedia <ref>{{Cite pmid|25181965 }}</ref> Edaravone protects human peripheral blood lymphocytes from ?-irradiation-induced apoptosis and DNA damage #MMPMID25181965 Chen L ; Liu Y ; Dong L ; Chu X Cell Stress Chaperones 2015[Mar]; 20 (2 ): 289-95 PMID25181965 show ga Radiation-induced cellular injury is attributed primarily to the harmful effects of free radicals, which play a key role in irradiation-induced apoptosis. In this study, we investigated the radioprotective efficacy of edaravone, a licensed clinical drug and a powerful free radical scavenger that has been tested against ?-irradiation-induced cellular damage in cultured human peripheral blood lymphocytes in studies of various diseases. Edaravone was pre-incubated with lymphocytes for 2 h prior to ?-irradiation. It was found that pretreatment with edaravone increased cell viability and inhibited generation of ?-radiation-induced reactive oxygen species (ROS) in lymphocytes exposed to 3 Gy ?-radiation. In addition, ?-radiation decreased antioxidant enzymatic activity, such as superoxide dismutase and glutathione peroxidase, as well as the level of reduced glutathione. Conversely, treatment with 100 ?M edaravone prior to irradiation improved antioxidant enzyme activity and increased reduced glutathione levels in irradiated lymphocytes. Importantly, we also report that edaravone reduced ?-irradiation-induced apoptosis through downregulation of Bax, upregulation of Bcl-2, and consequent reduction of the Bax:Bcl-2 ratio. The current study shows edaravone to be an effective radioprotector against ?-irradiation-induced cellular damage in lymphocytes in vitro. Finally, edaravone pretreatment significantly reduced DNA damage in ?-irradiated lymphocytes, as measured by comet assay (% tail DNA, tail length, tail moment, and olive tail moment) (p? |*Gamma Rays [MESH] |Adult [MESH] |Antipyrine/*analogs & derivatives/pharmacology [MESH] |Apoptosis/*drug effects/radiation effects [MESH] |Caspase 3/metabolism [MESH] |Cells, Cultured [MESH] |Comet Assay [MESH] |DNA Damage/*drug effects/radiation effects [MESH] |Edaravone [MESH] |Free Radical Scavengers/pharmacology [MESH] |Humans [MESH] |Lymphocytes/cytology/metabolism [MESH] |Poly(ADP-ribose) Polymerases/metabolism [MESH] |Proto-Oncogene Proteins c-bcl-2/metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH]Edaravone protects human peripheral blood lymphocytes from ?-irradiati(epmc).pdf DeepDyve Pubget Overpricing