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10.1128/AAC.04773-14 http://scihub22266oqcxt.onion/10.1128/AAC.04773-14 C4325814!4325814 !25583717     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25583717 &cmd=llinks): Failed to open stream: HTTP request failed! 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In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms |pdf=|usr=}}{{25583717 }} gab.com Text In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25583717 #FOAvip Pexiganan, a 22-amino-acid synthetic cationic peptide, is currently in phase 3 clinical trials as a topical antimicrobial agent for the treatment of mild infections associated with diabetic foot ulcers. Bacterial isolates from the 2013 SENTRY Antimicrobial Surveillance Program designated as pathogens from diabetic foot infections (DFI) and Gram-negative and -positive pathogens from various infection types that harbored selected resistance mechanisms/phenotypes were tested against pexiganan in reference cation-adjusted Mueller-Hinton broth. The MIC50 and MIC90 against all organisms tested from DFI were 16 and 32 ?g/ml, respectively. Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter cloacae, Acinetobacter species, and Pseudomonas aeruginosa MIC values ranged from 8 to 16 ?g/ml. Pexiganan MIC values among Staphylococcus aureus (methicillin-resistant S. aureus [MRSA] and methicillin-susceptible S. aureus [MSSA]), beta-hemolytic streptococci, and Enterococcus faecium ranged from 8 to 32 ?g/ml. Pexiganan activity was not adversely affected for members of the family Enterobacteriaceae or P. aeruginosa that produced ?-lactamases or resistance mechanisms to other commonly used antimicrobial agents. Decreased susceptibility to vancomycin did not affect pexiganan activity against S. aureus or E. faecium. Enterococcus faecalis appears to be intrinsically less susceptible to pexiganan (MIC, 32 to 256 ?g/ml). The "all organism" MIC90 of 32 ?g/ml for pexiganan in this study was >250-fold below the pexiganan concentration in the cream/delivery vehicle being developed for topical use. Twit Text FOAVip In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25583717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25583717 #FOAvip English Wikipedia <ref>{{Cite pmid|25583717 }}</ref> In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanisms #MMPMID25583717 Flamm RK ; Rhomberg PR ; Simpson KM ; Farrell DJ ; Sader HS ; Jones RN Antimicrob Agents Chemother 2015[Mar]; 59 (3 ): 1751-4 PMID25583717 show ga Pexiganan, a 22-amino-acid synthetic cationic peptide, is currently in phase 3 clinical trials as a topical antimicrobial agent for the treatment of mild infections associated with diabetic foot ulcers. Bacterial isolates from the 2013 SENTRY Antimicrobial Surveillance Program designated as pathogens from diabetic foot infections (DFI) and Gram-negative and -positive pathogens from various infection types that harbored selected resistance mechanisms/phenotypes were tested against pexiganan in reference cation-adjusted Mueller-Hinton broth. The MIC50 and MIC90 against all organisms tested from DFI were 16 and 32 ?g/ml, respectively. Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter cloacae, Acinetobacter species, and Pseudomonas aeruginosa MIC values ranged from 8 to 16 ?g/ml. Pexiganan MIC values among Staphylococcus aureus (methicillin-resistant S. aureus [MRSA] and methicillin-susceptible S. aureus [MSSA]), beta-hemolytic streptococci, and Enterococcus faecium ranged from 8 to 32 ?g/ml. Pexiganan activity was not adversely affected for members of the family Enterobacteriaceae or P. aeruginosa that produced ?-lactamases or resistance mechanisms to other commonly used antimicrobial agents. Decreased susceptibility to vancomycin did not affect pexiganan activity against S. aureus or E. faecium. Enterococcus faecalis appears to be intrinsically less susceptible to pexiganan (MIC, 32 to 256 ?g/ml). The "all organism" MIC90 of 32 ?g/ml for pexiganan in this study was >250-fold below the pexiganan concentration in the cream/delivery vehicle being developed for topical use. |Anti-Bacterial Agents/*pharmacology [MESH] |Antimicrobial Cationic Peptides/*pharmacology [MESH] |Diabetic Foot/*microbiology [MESH] |Drug Resistance, Bacterial/*drug effects [MESH] |Gram-Negative Bacteria/*drug effects [MESH] |Gram-Negative Bacterial Infections/drug therapy [MESH] |Gram-Positive Bacteria/*drug effects [MESH] |Gram-Positive Bacterial Infections/drug therapy [MESH] |Humans [MESH]In vitro spectrum of pexiganan activity when tested against pathogens (epmc).pdf DeepDyve Pubget Overpricing